Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 5/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 2/20 | 0.33 |
| ▸ | AGXT | P21549 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2545484 | 0.78 | LMNA (0.60) | LMNAPKMFFAR1FFAR4IDO1 | |
| SCHEMBL27776233 | 0.77 | MPO (0.37) | MPOSLC6A4PKMP2RX7FFAR1 | |
| SCHEMBL3100399 | 0.77 | FFAR1 (0.48) | LMNAPKMFFAR1FFAR4L3MBTL1 | |
| SCHEMBL20220477 | 0.76 | SLC6A4 (0.36) | SLC6A4PKMP2RX7IDO1AGXT | |
| SCHEMBL28922696 | 0.76 | PKM (0.49) | LMNAMPOSLC6A4PKMFFAR1 | |
| SCHEMBL28963079 | 0.74 | LMNA (0.38) | LMNAMPOSLC6A4PKMFFAR1 | |
| SCHEMBL3637969 | 0.74 | CA2 (0.46) | MPOSLC6A4PKMP2RX7CA2 | |
| SCHEMBL30817945 | 0.74 | CA2 (0.46) | MPOSLC6A4PKMP2RX7CA2 | |
| SCHEMBL27611364 | 0.73 | L3MBTL1 (0.45) | LMNAP2RX7L3MBTL1MEN1KMT2A | |
| SCHEMBL1345638 | 0.73 | P2RX7 (0.45) | MPOSLC6A4PKMP2RX7IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2155734-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2008144223-A2 | TRIAZOLYL AMINOPYRIMIDINE COMPOUNDS | ELI LILLY AND COMPANY (US) | 2008-11-27 | — | — | WO | disclosed |