Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.36 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2992907 | 0.85 | USP2 (0.46) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL16990245 | 0.82 | ABL1 (0.44) | LMNASMN1; SMN2ALDH1A1KDM4ETSHR | |
| SCHEMBL26983350 | 0.81 | LMNA (0.52) | L3MBTL1LMNASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL4262633 | 0.81 | LMNA (0.50) | L3MBTL1LMNASMN1; SMN2ALDH1A1TSHR | |
| SCHEMBL2991150 | 0.79 | APEX1 (0.40) | LMNATDO2ALDH1A1KDM4EGLA | |
| SCHEMBL12751738 | 0.78 | HTT (0.52) | L3MBTL1LMNAALDH1A1TSHR | |
| SCHEMBL4775470 | 0.76 | L3MBTL1 (0.63) | L3MBTL1LMNAALDH1A1GLATSHR | |
| SCHEMBL5307608 | 0.76 | ALDH1A1 (0.47) | L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL6111481 | 0.73 | HSD11B1 (0.48) | — | |
| SCHEMBL5303626 | 0.72 | RAB9A (0.47) | LMNAALDH1A1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162455-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | Glaxo Group Limited (GB) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008145688-A2 | PYRROLOPYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS | GLAXO GROUP LIMITED (GB) | 2008-12-04 | — | — | WO | disclosed |