Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Amidate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.97 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 0.97 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.97 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.52 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Etomidate SCHEMBL11323863 | 1.00 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| S-Etomidate SCHEMBL39486 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Etomidate SCHEMBL39487 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL39485 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1817757 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1098161 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL901536 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL21773562 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL22502728 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL11235297 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119935993-A | Method for detecting medetomidine hydrochloride and analogues thereof by using metalloporphyrin | 广东工业大学 | 2025-05-06 | — | — | CN | claimed |
| CN-119318635-A | Pharmaceutical preparation of N-substituted imidazole carboxylic acid ester chiral compound containing ether side chain and preparation method thereof | 锦州奥鸿药业有限责任公司 | 2025-01-17 | — | — | CN | claimed |
| CN-119097596-A | Injection containing methoxyetomidate hydrochloride and preparation method thereof | 锦州奥鸿药业有限责任公司 | 2024-12-10 | — | — | CN | claimed |
| CN-118090929-A | Analysis method for detecting content of enantiomer of methoxyetomidate hydrochloride | 锦州奥鸿药业有限责任公司 | 2024-05-28 | — | — | CN | claimed |
| US-4289783-A | Etomidate-containing compositions | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-09-15 | — | — | US | claimed |
| CN-119935993-A | Method for detecting medetomidine hydrochloride and analogues thereof by using metalloporphyrin | 广东工业大学 | 2025-05-06 | — | — | CN | disclosed |
| CN-119935993-A | Method for detecting medetomidine hydrochloride and analogues thereof by using metalloporphyrin | 广东工业大学 | 2025-05-06 | — | — | CN | disclosed |
| CN-119318635-A | Pharmaceutical preparation of N-substituted imidazole carboxylic acid ester chiral compound containing ether side chain and preparation method thereof | 锦州奥鸿药业有限责任公司 | 2025-01-17 | — | — | CN | disclosed |
| CN-119097596-A | Injection containing methoxyetomidate hydrochloride and preparation method thereof | 锦州奥鸿药业有限责任公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-119097596-A | Injection containing methoxyetomidate hydrochloride and preparation method thereof | 锦州奥鸿药业有限责任公司 | 2024-12-10 | — | — | CN | disclosed |
| CN-118090929-A | Analysis method for detecting content of enantiomer of methoxyetomidate hydrochloride | 锦州奥鸿药业有限责任公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-118090929-A | Analysis method for detecting content of enantiomer of methoxyetomidate hydrochloride | 锦州奥鸿药业有限责任公司 | 2024-05-28 | — | — | CN | disclosed |
| WO-2011131472-A1 | COMPOUNDS AND USES THEREOF TO INDUCE AN IMMUNOGENIC CANCER CELL DEATH IN A SUBJECT | INSTITUT GUSTAVE ROUSSY (FR) | 2011-10-27 | — | — | WO | disclosed |
| WO-2011131246-A1 | COMPOUNDS AND USES THEREOF TO INDUCE AN IMMUNOGENIC CANCER CELL DEATH IN A SUBJECT | INSTITUT GUSTAVE ROUSSY (FR) | 2011-10-27 | — | — | WO | disclosed |
| CN-1899087-A | Use of esterified amidates as feed additive | KANGDEQUAN FEED CO LTD HANGZHO (CN) | 2007-01-24 | — | — | CN | disclosed |
| US-5276053-A | Dibenzothiopyranylamines | WARNER-LAMBERT COMPANY (US) | 1994-01-04 | — | — | US | disclosed |
| US-5180736-A | Treatment and prevention of brain disorders | WARNER-LAMBERT COMPANY (US) | 1993-01-19 | — | — | US | disclosed |
| US-5071853-A | Amine-substituted hexahydroindeno(2,1-b)pyrroles, -indeno(2,1-c)pyridines or -indeno(2,1-d)azepines; cerebral ischemia or infarction | WARNER-LAMBERT COMPANY | 1991-12-10 | — | — | US | disclosed |
| EP-0388977-A2 | Polycyclic amines useful as cerebrovascular agents | WARNER-LAMBERT COMPANY (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4289783-A | Etomidate-containing compositions | JANSSEN PHARMACEUTICA, N.V. (BE) | 1981-09-15 | — | — | US | disclosed |