Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Amidate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.97 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 0.97 |
| ▸ | GABRA2 known ✓ | P47869 | 1/20 | 0.97 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.97 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.97 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | GPBAR1 | Q8TDU6 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amidate SCHEMBL39485 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Etomidate SCHEMBL39487 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| S-Etomidate SCHEMBL39486 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL1817757 | 0.99 | GABRA1 (1.00) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL363786 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL901536 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL21773562 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL22502728 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL668471 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 | |
| Amidate SCHEMBL11235297 | 0.97 | GABRA1 (0.97) | GABRA1GABRB2CYP11B2CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1765844-B1 | PURINE NUCLEOTIDE DERIVATIVES | SOLVELL AS (NO) | 2014-07-30 | — | — | EP | disclosed |
| US-8153609-B2 | Purine nucleotide derivatives | LAURAS AS (NO) | 2012-04-10 | — | — | US | disclosed |
| US-20080293665-A1 | Purine Nucleotide Derivatives | LAURAS AS (NO) | 2008-11-27 | — | — | US | disclosed |
| EP-1765844-A2 | PURINE NUCLEOTIDE DERIVATIVES | Lauras AS (NO) | 2007-03-28 | — | — | EP | disclosed |
| WO-2005123755-A2 | PURINE NUCLEOTIDE DERIVATIVES | LAURAS AS (NO) | 2005-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080293665-A1 | Purine Nucleotide Derivatives | CGAS, PDE8A, PDE7A | GABRA1 1926/4885GABRB2 2390/4885GABRA2 2153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.