Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | NLRP1 | Q9C000 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL135383 | 0.81 | GSK3B (0.55) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL2118359 | 0.79 | KMT2A (0.60) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL29202459 | 0.78 | LMNA (0.42) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL11430930 | 0.78 | GSK3B (0.59) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL11450666 | 0.78 | NPC1 (0.53) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL6379810 | 0.78 | HDAC3 (0.61) | GSK3BNPC1RAB9AALDH1A1LMNA | |
| SCHEMBL11396201 | 0.78 | KMT2A (0.47) | NPC1RAB9AKMT2AMEN1ALDH1A1 | |
| SCHEMBL571114 | 0.77 | TDP1 (0.58) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL600578 | 0.77 | RAB9A (0.83) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL16552778 | 0.77 | KMT2A (0.83) | GSK3BNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2176278-A2 | 2',3'-DI-O-ACYL-5-FLUORONUCLEOSIDES | Innovate Biotechnology S.R.L. (IT) | 2010-04-21 | — | — | EP | disclosed |
| WO-2008107771-A2 | 2',3'-DI-O-ACYL-5-FLUORONUCLEOSIDES | INNOVATE BIOTECHNOLOGY S.R.L. (IT) | 2008-09-12 | — | — | WO | disclosed |