Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3591477 | 0.83 | CES2 (0.50) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL13622409 | 0.79 | LMNA (0.56) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL28310232 | 0.79 | MAPT (0.46) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL3899593 | 0.78 | HTT (0.52) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL3641682 | 0.78 | GSK3B (0.57) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL7701905 | 0.78 | ALDH1A1 (0.53) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL1726590 | 0.76 | GSK3B (0.61) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL3269069 | 0.76 | HTT (0.50) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL30187429 | 0.76 | GSK3B (0.61) | KMT2AMEN1HTTSMN1; SMN2CES2 | |
| SCHEMBL8424293 | 0.76 | GSK3B (0.52) | KMT2AMEN1HTTSMN1; SMN2CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0016277-A1 | 2-Carbonyl-3-hydroxy-alkenonitriles, their use as anti-arthritic agents and processes for their preparation | AMERICAN CYANAMID COMPANY (US) | 1980-10-01 | — | — | EP | disclosed |
| WO-1980000964-A1 | ANTI-INFLAMMATORY AGENTS INCLUDING 2-CARBONYL-3-HYDROXY-2-ALKENONITRILES | AMERICAN CYANAMID CO (US) | 1980-05-15 | — | — | WO | disclosed |