Sugi Predict

Sugi Predict / Compounds / SCHEMBL365017

SCHEMBL365017

SCHEMBL365017

Cc1cc(F)c(C(=O)O)cc1F

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 4/20 0.44
▸ ASPH Q12797 1/20 0.44
▸ KDM8 Q8N371 1/20 0.44
▸ KEAP1 Q14145 1/20 0.44
▸ NFE2L2 Q16236 1/20 0.44
▸ NOTUM Q6P988 3/20 0.41
▸ HSD17B10 Q99714 3/20 0.40
▸ ALDH1A1 P00352 2/20 0.40
▸ HPGD P15428 2/20 0.39
▸ GAA P10253 1/20 0.39
▸ HMGB1 P09429 1/20 0.38
▸ CXCL12 P48061 1/20 0.38
▸ GABRP O00591 1/20 0.38
▸ GABRD O14764 1/20 0.38
▸ GABRA1 P14867 1/20 0.38
▸ GABRB1 P18505 1/20 0.38
▸ GABRG2 P18507 1/20 0.38
▸ GABRB3 P28472 1/20 0.38
▸ GABRA5 P31644 1/20 0.38
▸ GABRA3 P34903 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11948576 0.91 KDM4E (0.44) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL3436916 0.88 KDM4E (0.45) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL12593947 0.88 KDM4E (0.45) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL1418105 0.86 KDM4E (0.44) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL12931050 0.86 KDM4E (0.44) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL27523055 0.86 KDM4E (0.44) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL19399612 0.86 KEAP1 (0.44) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL1713733 0.85 KDM4E (0.54) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL27887 0.84 KEAP1 (0.45) KDM4EASPHKDM8KEAP1NFE2L2
SCHEMBL1264547 0.83 CSNK2A1 (0.44) KDM4EASPHKDM8NOTUMHSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 92 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250313556-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS RETUNE PHARMA, INC. 2025-10-09 — — US disclosed
EP-4605394-A1 PYRIMIDINE SGC STIMULATORS Tisento Therapeutics Inc. (US) 2025-08-27 — — EP disclosed
EP-4514799-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS MRJA Therapeutics, Inc. (US) 2025-03-05 — — EP disclosed
CN-119384421-A Certain chemical entities, compositions and methods 沐尔佳治疗公司 2025-01-28 — — CN disclosed
WO-2024086179-A1 PYRIMIDINE SGC STIMULATORS TISENTO THERAPEUTICS, INC. (US) 2024-04-25 — — WO disclosed
WO-2023212612-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS QIAN SHAWN (US) 2023-11-02 — — WO disclosed
WO-2023212612-A2 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS QIAN SHAWN (US) 2023-11-02 — — WO disclosed
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS VERTEX PHARMACEUTICALS INCORPORATED (US) 2023-09-14 — — US disclosed
US-11203571-B2 Sulfonamides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2021-12-21 — — US disclosed
US-11203571-B2 Sulfonamides as modulators of sodium channels VERTEX PHARMACEUTICALS INCORPORATED (US) 2021-12-21 — — US disclosed
WO-2012007861-A1 N-SULFONYLBENZAMIDE DERIVATIVES USEFUL AS VOLTAGE GATED SODIUM CHANNEL INHIBITORS PFIZER LIMITED (GB) 2012-01-19 — — WO disclosed
WO-2012007869-A2 CHEMICAL COMPOUNDS PFIZER LIMITED (GB) 2012-01-19 — — WO disclosed
WO-2012007868-A2 CHEMICAL COMPOUNDS PFIZER LIMITED (GB) 2012-01-19 — — WO disclosed
US-20120010183-A1 Chemical Compounds PFIZER LIMITED (GB) 2012-01-12 — — US disclosed
US-20110092494-A1 Tricyclic Tetrahydroquinoline Antibacterial Agents PHARMACIA & UPJOHN COMPANY 2011-04-21 — — US disclosed
US-20100249088-A1 AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-09-30 — — US disclosed
US-20100029687-A1 PIPERIDINE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-02-04 — — US disclosed
US-20100029687-A1 PIPERIDINE DERIVATIVE OR SALT THEREOF ASTELLAS PHARMA INC. (JP) 2010-02-04 — — US disclosed
US-4762844-A ANIMAL GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1988-08-09 — — US disclosed
EP-0181588-A2 Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids, process for their preparation, and antibacterial agents containing them BAYER AG (DE) 1986-05-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110092494-A1 Tricyclic Tetrahydroquinoline Antibacterial Agents QTRT1, QTRT2, NQO2 KDM4E 1604/4885ASPH 3677/4885KDM8 3667/4885
US-20120010183-A1 Chemical Compounds SCN1A, SCN1B, SCN7A KDM4E 3227/4885ASPH 3823/4885KDM8 3856/4885
US-20250313556-A1 CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS KIT, PRKCH, PRKCB KDM4E 1120/4885ASPH 2388/4885KDM8 755/4885
US-20100029687-A1 PIPERIDINE DERIVATIVE OR SALT THEREOF CASR, CYP2R1, HCAR1 KDM4E 2417/4885ASPH 610/4885KDM8 1336/4885
US-20100249088-A1 AZOLECARBOXAMIDE COMPOUND OR SALT THEREOF TRPV1, FGFR3, GPR17 KDM4E 1395/4885ASPH 3466/4885KDM8 524/4885
US-11203571-B2 Sulfonamides as modulators of sodium channels TRPV1, SCN1A, SCN5A KDM4E 1856/4885ASPH 1437/4885KDM8 3358/4885
US-20230286907-A1 CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS TRPV1, SCN2A, SCN10A KDM4E 1582/4885ASPH 2596/4885KDM8 2263/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.