Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR1E | P28566 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL640081 | 0.75 | KIF11 (0.39) | ALDH1A1HTTHSD17B10GPR3MAPT | |
| SCHEMBL5327645 | 0.75 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTDRD3HSD17B10 | |
| SCHEMBL7404828 | 0.75 | HTR2A (0.36) | ALDH1A1LMNAHTTHTR1DHTR2A | |
| SCHEMBL3381548 | 0.75 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTHSD17B10GPR3 | |
| SCHEMBL10505940 | 0.73 | GABRA1 (0.35) | ALDH1A1HTR1AHTR1DHTR2AHTR2C | |
| SCHEMBL16432092 | 0.72 | TAAR1 (0.46) | ALDH1A1HTR1DHTR2AHTR2CSLC6A4 | |
| SCHEMBL6709570 | 0.72 | KMT2A (0.46) | ALDH1A1HTTHTR6HSD17B10MAPT | |
| SCHEMBL6470274 | 0.72 | CHRNB2 (0.41) | ALDH1A1HTR2AHSD17B10GPR3RAB9A | |
| SCHEMBL928608 | 0.70 | ALDH1A1 (0.47) | ALDH1A1LMNAHTR1AHTR2AHTR2C | |
| SCHEMBL4142895 | 0.69 | KDM4E (0.42) | ALDH1A1HSD17B10RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 109 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116217505-A | Novel marker targeting agents for diagnosis or treatment of cancers expressing prostate specific membrane antigen | 南京医科大学 | 2023-06-06 | — | — | CN | claimed |
| EP-4021447-A1 | METHODS AND USES FOR APELIN RECEPTOR AGONISTS | Research Triangle Institute (US) | 2022-07-06 | — | — | EP | claimed |
| WO-2021041791-A1 | METHODS AND USES FOR APELIN RECEPTOR AGONISTS | RTI INTERNATIONAL, INC. (US) | 2021-03-04 | — | — | WO | claimed |
| US-20190345143-A1 | HEPARANASE INHIBITORS AND USE THEREOF | Beta Therapeutics Pty Ltd (AU) | 2019-11-14 | — | — | US | claimed |
| EP-3555071-A1 | HEPARANASE INHIBITORS AND USE THEREOF | Beta Therapeutics Pty. Ltd. (AU) | 2019-10-23 | — | — | EP | claimed |
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RES TRIANGLE INST (US) | 2019-10-17 | — | — | US | claimed |
| WO-2018107201-A1 | HEPARANASE INHIBITORS AND USE THEREOF | Beta Therapeutics Pty Ltd (AU) | 2018-06-21 | — | — | WO | claimed |
| EP-3152200-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | Research Triangle Institute (US) | 2017-04-12 | — | — | EP | claimed |
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE | 2016-07-21 | — | — | US | claimed |
| WO-2015188073-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | RESEARCH TRIANGLE INSTITUTE (US) | 2015-12-10 | — | — | WO | claimed |
| WO-1998030553-A1 | TAXOID REVERSAL AGENTS FOR DRUG-RESISTANCE IN CANCER CHEMOTHERAPY AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK (US) | 1998-07-16 | — | — | WO | claimed |
| US-5703106-A | TREATING VARIOUS CARDIOVASCULAR, UROGENITAL, BRAIN DISORDERS | JAPAT LTD. (CH) | 1997-12-30 | — | — | US | claimed |
| EP-0753004-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | Japat Ltd (CH) | 1997-01-15 | — | — | EP | claimed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | claimed |
| WO-1995026360-A1 | ANTAGONISTS OF ENDOTHELIN RECEPTORS | JAPAT LTD. (CH) | 1995-10-05 | — | — | WO | claimed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | claimed |
| EP-0156456-B1 | [(1,3,-dioxo-1,3-propanediyl)diimino] bisbenzoic acid derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1989-11-15 | — | — | EP | claimed |
| EP-0156456-A1 | [(1,3,-dioxo-1,3-propanediyl)diimino] bisbenzoic acid derivatives and their use | SAWAI PHARMACEUTICAL CO., LTD. (JP) | 1985-10-02 | — | — | EP | claimed |
| US-4396616-A | DIURETICS, ENZYME INHIBITORS | MERCK & CO., INC. (US) | 1983-08-02 | — | — | US | claimed |
| EP-0012401-A1 | Carboxyalkyl dipeptide derivatives, process for preparing them and pharmaceutical composition containing them | MERCK & CO. INC. (US) | 1980-06-25 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207889-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | ALDH1A1 3849/4885LMNA 2587/4885HTT 2954/4885 |
| US-20190345143-A1 | HEPARANASE INHIBITORS AND USE THEREOF | HPSE, HEXD, ENGASE | ALDH1A1 1394/4885LMNA 2952/4885HTT 107/4885 |
| US-20190315693-A1 | APELIN RECEPTOR (APJ) AGONISTS AND USES THEREOF | APLNR, AP1G1, APMAP | ALDH1A1 3849/4885LMNA 2587/4885HTT 2954/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.