Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367409 | 0.91 | EPHX1 (0.48) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL367237 | 0.87 | TSHR (0.49) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL365101 | 0.83 | KMT2A (0.51) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL366114 | 0.78 | TSHR (0.47) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL365256 | 0.78 | EGFR (0.40) | KMT2ANPC1RAB9AMEN1TSHR | |
| SCHEMBL365263 | 0.76 | EPHX1 (0.47) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL365668 | 0.75 | KMT2A (0.55) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL367245 | 0.75 | EGFR (0.33) | KMT2ANPC1MEN1 | |
| SCHEMBL365100 | 0.75 | EPHX1 (0.52) | EPHX1HSD17B10KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL367222 | 0.72 | EGFR (0.41) | HSD17B10NPC1TSHRCYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |