Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.41 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | BAZ2B | Q9UIF8 | 2/20 | 0.36 |
| ▸ | BAZ2A | Q9UIF9 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365771 | 0.92 | EGFR (0.43) | EGFRSRCBAZ2BBAZ2AHTR2A | |
| SCHEMBL365023 | 0.92 | EGFR (0.40) | EGFRSRCHTR2AHTR2CELANE | |
| SCHEMBL367256 | 0.92 | EGFR (0.40) | EGFRSRCPARP1BAZ2BBAZ2A | |
| SCHEMBL367766 | 0.81 | L3MBTL1 (0.43) | EGFRSRCPARP1NPC1MAPT | |
| SCHEMBL366821 | 0.81 | AGTR1 (0.41) | EGFRSRCPOLBCYP3A4MAPT | |
| SCHEMBL365789 | 0.79 | EGFR (0.41) | EGFRSRCBAZ2BBAZ2APOLB | |
| SCHEMBL365256 | 0.76 | EGFR (0.40) | EGFRSRCNPC1TSHR | |
| SCHEMBL367764 | 0.76 | EGFR (0.45) | EGFRSRCPARP1HTR2AHTR2C | |
| SCHEMBL366567 | 0.76 | PSEN1 (0.38) | EGFRSRCPOLBMAPTTSHR | |
| SCHEMBL366790 | 0.75 | EGFR (0.41) | EGFRSRCPOLBCYP3A4HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |