SCHEMBL365385

SCHEMBL365385

O=c1ccoc2ccc(Cl)cc12

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOA P21397 9/20 0.58
MAOB P27338 9/20 0.58
FTO Q9C0B1 2/20 0.55
ALDH1A1 P00352 2/20 0.54
KDM4E B2RXH2 2/20 0.54
HPGD P15428 1/20 0.54
TSHR P16473 1/20 0.54
HSD17B10 Q99714 1/20 0.54
ACHE P22303 1/20 0.53
ADCY1 Q08828 1/20 0.51
DYRK1A Q13627 1/20 0.51
PTPN1 P18031 1/20 0.50
TNKS O95271 1/20 0.49
ADORA3 P0DMS8 1/20 0.49
GABRP O00591 2/20 0.47
GABRD O14764 2/20 0.47
GABRA1 P14867 2/20 0.47
GABRB1 P18505 2/20 0.47
GABRG2 P18507 2/20 0.47
GABRB3 P28472 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Benzene SCHEMBL27821367 0.96 ACHE (0.58) MAOAMAOBFTOALDH1A1KDM4E
Ethane SCHEMBL27840767 0.96 MAOA (0.55) MAOAMAOBFTOALDH1A1KDM4E
SCHEMBL7022124 0.87 MAOA (0.48) MAOAMAOBFTOALDH1A1KDM4E
SCHEMBL28230155 0.83 FTO (0.63) MAOAMAOBFTOALDH1A1KDM4E
SCHEMBL3681299 0.78 FTO (0.61) MAOAMAOBFTOALDH1A1KDM4E
SCHEMBL7617877 0.78 FTO (0.72) MAOAMAOBFTOALDH1A1HPGD
SCHEMBL13665731 0.78 MAOA (0.53) MAOAMAOBFTOKDM4EACHE
SCHEMBL1094182 0.78 MAOA (0.59) MAOAMAOBFTOKDM4EACHE
SCHEMBL21303291 0.78 MAOA (0.53) MAOAMAOBFTOKDM4EACHE
SCHEMBL1166873 0.78 DYRK1A (0.58) MAOAMAOBFTOKDM4EACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117285925-A Ratio fluorescence and colorimetric dual-mode reagent for detecting ethylenediamine based on electron energy transfer mechanism 中国科学院新疆理化技术研究所 2023-12-26 CN claimed
EP-2363127-A1 PPAR Modulators Evolva SA (CH) 2011-09-07 EP claimed
US-20110178112-A1 PPAR Modulators EVOLVA SA (CH) 2011-07-21 US claimed
EP-1976509-A2 PPAR MODULATORS Evolva SA (CH) 2008-10-08 EP claimed
WO-2007138485-A2 PPAR MODULATORS EVOLVA SA (US) 2007-12-06 WO claimed
CN-117551092-A Chromone compound containing 5-sulfone-1, 3, 4-thiadiazole, preparation method and sterilization application thereof 南京农业大学 2024-02-13 CN disclosed
CN-117285925-A Ratio fluorescence and colorimetric dual-mode reagent for detecting ethylenediamine based on electron energy transfer mechanism 中国科学院新疆理化技术研究所 2023-12-26 CN disclosed
CN-114560837-B Chromone compound and preparation method and application thereof 五邑大学 2023-11-24 CN disclosed
CN-114560837-A Chromone compound and preparation method and application thereof 五邑大学 2022-05-31 CN disclosed
EP-3960172-A1 ANTIFUNGAL COMPOSITION Seed Research Institute Co., Ltd. (JP) 2022-03-02 EP disclosed
CN-111848451-B Preparation method of cyano compound 中国科学院化学研究所 2021-08-24 CN disclosed
CN-111848451-A Preparation method of cyano compound 中国科学院化学研究所 2020-10-30 CN disclosed
US-20080300298-A1 Honokiol Derivates For the Treatment of Proliferative Disorders NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2008-12-04 US disclosed
EP-1976509-A2 PPAR MODULATORS Evolva SA (CH) 2008-10-08 EP disclosed
WO-2008089461-A1 SUBSTITUTED 1,3-DIOXANES USEFUL AS PPAR MODULATORS EVOLVA SA (CH) 2008-07-24 WO disclosed
WO-2007138485-A2 PPAR MODULATORS EVOLVA SA (US) 2007-12-06 WO disclosed
US-20060281711-A1 IL-12 modulatory compounds SYNTA PHARMACEUTICALS CORP. (US) 2006-12-14 US disclosed
WO-2006124662-A1 IL-12 MODULATORY COMPOUNDS SYNTA PHARMACEUTICALS CORP. (US) 2006-11-23 WO disclosed
US-20060211636-A1 Macrolide Antibiotics ALIHODZIC SULEJMAN 2006-09-21 US disclosed
US-4153707-A Fungicidal isoxazolyl phenols and method of use THE UPJOHN COMPANY (US) 1979-05-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060281711-A1 IL-12 modulatory compounds IL2, IL4, IL15 MAOA 2199/4885MAOB 2302/4885FTO 4633/4885
US-20110178112-A1 PPAR Modulators PPARD, PPARG, PPARA MAOA 4127/4885MAOB 4196/4885FTO 3818/4885
US-20060211636-A1 Macrolide Antibiotics IL1R1, MRPL12, RPS21 MAOA 4469/4885MAOB 3949/4885FTO 2611/4885
US-20080300298-A1 Honokiol Derivates For the Treatment of Proliferative Disorders CCNK, CDK3, CCNO MAOA 4495/4885MAOB 3989/4885FTO 4883/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.