Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 8/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | HTR1D | P28221 | 1/20 | 0.36 |
| ▸ | HTR1B | P28222 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL366693 | 0.89 | ALDH1A1 (0.47) | MEN1KMT2AHTR6GAAALDH1A1 | |
| SCHEMBL366133 | 0.88 | AGTR1 (0.41) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL366858 | 0.87 | KMT2A (0.43) | MEN1KMT2ANR4A2GAALMNA | |
| SCHEMBL364606 | 0.87 | HTR6 (0.38) | HTR6EGFRSRCHTR1ADRD2 | |
| SCHEMBL365521 | 0.83 | KMT2A (0.43) | MEN1KMT2AGAALMNASMN1; SMN2 | |
| SCHEMBL364787 | 0.83 | KMT2A (0.45) | MEN1KMT2ANR4A2GAALMNA | |
| SCHEMBL365826 | 0.81 | KMT2A (0.48) | MEN1KMT2ANR4A2GAALMNA | |
| SCHEMBL364955 | 0.81 | CASP3 (0.40) | MEN1KMT2ANR4A2GAALMNA | |
| SCHEMBL365427 | 0.80 | ALDH1A1 (0.48) | MEN1KMT2ANR4A2GAALMNA | |
| SCHEMBL366738 | 0.79 | KMT2A (0.46) | MEN1KMT2ANR4A2GAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |