Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 6/20 | 0.41 |
| ▸ | HTR6 | P50406 | 13/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR1F | P30939 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364606 | 0.90 | HTR6 (0.38) | AGTR1HTR6HTR1ADRD2HTR1D | |
| SCHEMBL365522 | 0.88 | MEN1 (0.41) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL366693 | 0.86 | ALDH1A1 (0.47) | HTR6HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL366132 | 0.82 | ALDH1A1 (0.38) | AGTR1HTR6HTR1ADRD2HTR1D | |
| SCHEMBL366462 | 0.82 | LMNA (0.46) | AGTR1 | |
| SCHEMBL367747 | 0.80 | AGTR1 (0.48) | AGTR1 | |
| SCHEMBL365648 | 0.77 | CA9 (0.45) | AGTR1 | |
| SCHEMBL366536 | 0.74 | EGFR (0.53) | — | |
| SCHEMBL366858 | 0.74 | KMT2A (0.43) | — | |
| SCHEMBL365147 | 0.73 | AGTR1 (0.39) | AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |