Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CBFB | Q13951 | 1/20 | 0.35 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3655146 | 0.90 | CBFB (0.36) | ALDH1A1KDM4EHTTL3MBTL1CBFB | |
| SCHEMBL3655959 | 0.83 | ADORA3 (0.42) | ALDH1A1KDM4EALOX15MAPTHPGD | |
| SCHEMBL733150 | 0.79 | GABRG2 (0.44) | ALDH1A1KDM4ESMN1; SMN2NEK1CDK8 | |
| SCHEMBL3800296 | 0.78 | ROCK2 (0.39) | ALDH1A1HTT | |
| SCHEMBL2203896 | 0.78 | ATAD2 (0.46) | ALDH1A1KDM4EHTTALOX15MAPT | |
| SCHEMBL3659131 | 0.76 | HPGDS (0.39) | ALDH1A1KDM4EMAPTPOLBCDK8 | |
| SCHEMBL3658350 | 0.76 | MAPT (0.45) | ALDH1A1KDM4EMAPTHPGDPOLB | |
| SCHEMBL2512905 | 0.75 | KDM4E (0.48) | ALDH1A1KDM4EMAPTHPGDL3MBTL1 | |
| SCHEMBL1505455 | 0.75 | GABRG2 (0.50) | ALDH1A1MAPTHPGDNEK1CDK8 | |
| SCHEMBL2203174 | 0.73 | TP53 (0.56) | ALDH1A1MAPTHPGDL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2205573-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2010-07-14 | — | — | EP | disclosed |
| WO-2009043780-A1 | TETRAZOLE-SUBSTITUTED ARYL AMIDE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2009-04-09 | — | — | WO | disclosed |