Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | PHGDH | O43175 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365229 | 0.89 | HPGD (0.48) | HPGDTSHRCNR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL365335 | 0.86 | CNR2 (0.47) | HPGDCNR2ALDH1A1CNR1KDM4E | |
| SCHEMBL367332 | 0.81 | HPGD (0.50) | HPGDTSHRCNR2SMN1; SMN2GAA | |
| SCHEMBL365668 | 0.80 | KMT2A (0.55) | HPGDTSHRSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL365935 | 0.80 | KDM4E (0.47) | HPGDALDH1A1KDM4ECYP1A2POLB | |
| SCHEMBL366310 | 0.77 | ALDH1A1 (0.52) | HPGDSMN1; SMN2ALDH1A1CNR1KDM4E | |
| SCHEMBL366876 | 0.76 | EGFR (0.44) | HPGDSMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL366811 | 0.76 | EGFR (0.44) | HPGDTSHRALDH1A1KDM4EPOLB | |
| SCHEMBL367205 | 0.73 | EGFR (0.45) | HPGDALDH1A1KDM4EHDAC1HDAC6 | |
| SCHEMBL365912 | 0.73 | CES1 (0.45) | HPGDALDH1A1KDM4ECYP1A2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |