Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPR132 | Q9UNW8 | 5/20 | 0.36 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | CMKLR2 | P46091 | 1/20 | 0.34 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367193 | 0.92 | GPR132 (0.38) | KDM4EALDH1A1GPR132SLC1A5MET | |
| SCHEMBL366015 | 0.92 | CYP11B1 (0.37) | KDM4EMEN1ALDH1A1KMT2ACYP19A1 | |
| SCHEMBL365081 | 0.85 | KDM4E (0.38) | KDM4EMEN1ALDH1A1KMT2APIM1 | |
| SCHEMBL364642 | 0.84 | CYP11B1 (0.40) | KDM4EALDH1A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL364640 | 0.83 | ALDH1A1 (0.39) | KDM4EMEN1ALDH1A1KMT2ASIRT2 | |
| SCHEMBL367224 | 0.81 | ALDH1A1 (0.43) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL366566 | 0.80 | ALDH1A1 (0.44) | KDM4EMEN1ALDH1A1KMT2A | |
| SCHEMBL365965 | 0.79 | ACVR2A (0.38) | KDM4EGPR132METLCKSGMS2 | |
| SCHEMBL367248 | 0.77 | ALDH1A1 (0.37) | KDM4EMEN1ALDH1A1KMT2ASIRT2 | |
| SCHEMBL365785 | 0.77 | ALDH1A1 (0.38) | KDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |