Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 7/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.35 |
| ▸ | GCK | P35557 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364642 | 0.92 | CYP11B1 (0.40) | CYP11B1CYP11B2CYP19A1MKNK1MKNK2 | |
| SCHEMBL365964 | 0.92 | KDM4E (0.36) | CYP11B1CYP11B2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL364640 | 0.90 | ALDH1A1 (0.39) | KDM4EALDH1A1MEN1KMT2APDE4A | |
| SCHEMBL366694 | 0.85 | MKNK1 (0.41) | CYP11B1CYP11B2CYP19A1MKNK1MKNK2 | |
| SCHEMBL367248 | 0.84 | ALDH1A1 (0.37) | KDM4EALDH1A1MEN1KMT2AHSD17B10 | |
| SCHEMBL365785 | 0.84 | ALDH1A1 (0.38) | KDM4EALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL367193 | 0.84 | GPR132 (0.38) | KDM4EALDH1A1HSD17B10 | |
| SCHEMBL366072 | 0.83 | FFAR1 (0.37) | CYP11B1CYP11B2CYP19A1KDM4EALDH1A1 | |
| SCHEMBL366806 | 0.80 | ALDH1A1 (0.35) | KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL367224 | 0.80 | ALDH1A1 (0.43) | MKNK2KDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |