Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR2A | P27037 | 1/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GPR132 | Q9UNW8 | 2/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | SNCA | P37840 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367194 | 0.92 | GPR132 (0.38) | CYP1A2CYP3A4CYP2C9HTTGPR132 | |
| SCHEMBL366016 | 0.92 | MAPK12 (0.39) | CYP1A2CYP3A4CYP2C9HTTKDM4E | |
| SCHEMBL365082 | 0.85 | CYP11B2 (0.40) | CYP1A2CYP3A4CYP2C9KDM4EHTR1A | |
| SCHEMBL364643 | 0.84 | CYP11B1 (0.40) | CYP1A2CYP3A4CYP2C9HTTKDM4E | |
| SCHEMBL364641 | 0.83 | PLK1 (0.38) | DRD2 | |
| SCHEMBL367225 | 0.82 | KMT2A (0.40) | HTTKDM4ELMNATSHR | |
| SCHEMBL366567 | 0.80 | PSEN1 (0.38) | HTTKDM4ETSHR | |
| SCHEMBL365964 | 0.79 | KDM4E (0.36) | ACVR2ATGFBR2KDM4EGPR132MET | |
| SCHEMBL367249 | 0.78 | MEN1 (0.36) | HTTLMNA | |
| SCHEMBL365786 | 0.78 | ALDH1A1 (0.38) | HTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |