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SCHEMBL366040

SCHEMBL366040

O=[N+]([O-])c1nccn1Cc1cn(C(CO)CF)nn1

nearest known ligand 0.41

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ TYMP P19971 3/20 0.41
▸ LMNA P02545 1/20 0.40
▸ THRB P10828 1/20 0.40
▸ CYP2C19 P33261 1/20 0.40
▸ KMT2A Q03164 1/20 0.39
▸ CA12 O43570 4/20 0.36
▸ CA1 P00915 4/20 0.36
▸ CA2 P00918 4/20 0.36
▸ CA9 Q16790 4/20 0.36
▸ CYP3A4 P08684 1/20 0.35
▸ CYP2D6 P10635 1/20 0.35
▸ OPRK1 P41145 1/20 0.35
▸ KCNH2 Q12809 8/20 0.33
▸ CYP19A1 P11511 2/20 0.33
▸ GRIN2B Q13224 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12427863 1.00 TYMP (0.41) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL14043101 0.93 TYMP (0.44) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL12427867 0.89 TYMP (0.41) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL12427959 0.89 TYMP (0.41) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL17613421 0.86 TYMP (0.39) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL13104162 0.86 TYMP (0.39) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL12427955 0.85 TYMP (0.37) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL942630 0.83 LMNA (0.38) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL16367291 0.83 TYMP (0.37) TYMPLMNATHRBCYP2C19KMT2A
SCHEMBL15560936 0.80 CYP19A1 (0.33) CYP19A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250339712-A1 ADAPTIVE CORRELATION FILTER FOR RADIOTHERAPY REFLEXION MEDICAL INC (US) 2025-11-06 — — US disclosed
EP-4619094-A1 ADAPTIVE CORRELATION FILTER FOR RADIOTHERAPY RefleXion Medical, Inc. (US) 2025-09-24 — — EP disclosed
WO-2024107734-A1 ADAPTIVE CORRELATION FILTER FOR RADIOTHERAPY REFLEXION MEDICAL, INC. (US) 2024-05-23 — — WO disclosed
US-11242314-B2 Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride WASHINGTON UNIVERSITY (US) 2022-02-08 — — US disclosed
US-20190328687-A1 Antibacterial Compounds VICTORIA LINK LIMITED (NZ) 2019-10-31 — — US disclosed
US-10392344-B2 Method for preparing fluorine-18 eluent with adjusted PH, and method for labelling fluorine-18 using same THE ASAN FOUNDATION (KR) 2019-08-27 — — US disclosed
US-10357577-B2 Bacterial nitroreductase enzymes and methods relating thereto AUCKLAND UNISERVICES LIMITED (NZ) 2019-07-23 — — US disclosed
EP-3220919-A1 ANTIBACTERIAL COMPOUNDS Victoria Link Limited (NZ) 2017-09-27 — — EP disclosed
WO-2016080846-A1 ANTIBACTERIAL COMPOUNDS COPP JANINE NAOMI (NZ) 2016-05-26 — — WO disclosed
EP-2132200-B1 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS THRESHOLD PHARMACEUTICALS INC (US) 2016-03-23 — — EP disclosed
US-20110002850-A1 Nitro-Imidazole Hypoxia Imaging Agent SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2011-01-06 — — US disclosed
US-7807394-B2 Nitro-imidazole hypoxia imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2010-10-05 — — US disclosed
US-7807394-B2 Nitro-imidazole hypoxia imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2010-10-05 — — US disclosed
US-7807394-B2 Nitro-imidazole hypoxia imaging agents SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2010-10-05 — — US disclosed
EP-2132200-A2 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS Siemens Medical Solutions USA, Inc. (US) 2009-12-16 — — EP disclosed
US-20090010846-A1 Nitro-Imidazole Hypoxia Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-01-08 — — US disclosed
US-20090010846-A1 Nitro-Imidazole Hypoxia Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-01-08 — — US disclosed
US-20090010846-A1 Nitro-Imidazole Hypoxia Imaging Agents SIEMENS MEDICAL SOLUTIONS USA, INC. 2009-01-08 — — US disclosed
WO-2008124651-A2 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2008-10-16 — — WO disclosed
WO-2008124651-A2 NITRO-IMIDAZOLE HYPOXIA IMAGING AGENTS SIEMENS MEDICAL SOLUTIONS USA, INC. (US) 2008-10-16 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090010846-A1 Nitro-Imidazole Hypoxia Imaging Agents HIF1AN, HIF1A, HYOU1 TYMP 781/4885LMNA 3765/4885THRB 2300/4885
US-11242314-B2 Synthesizing pet tracers using [F-18]sulfonyl fluoride as a source of [F-18]fluoride STX18, GPR119, SLC5A1 TYMP 4403/4885LMNA 4793/4885THRB 1899/4885
US-10392344-B2 Method for preparing fluorine-18 eluent with adjusted PH, and method for labelling fluorine-18 using same PHF8, AFF1, F8 TYMP 3724/4885LMNA 4135/4885THRB 3417/4885
US-20110002850-A1 Nitro-Imidazole Hypoxia Imaging Agent HIF1AN, HIF1A, HYOU1 TYMP 797/4885LMNA 3725/4885THRB 2243/4885
US-20190328687-A1 Antibacterial Compounds SHARPIN, FDPS, BROX TYMP 2049/4885LMNA 4196/4885THRB 3981/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.