Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV4 | Q9HBA0 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.38 |
| ▸ | ACLY | P53396 | 2/20 | 0.38 |
| ▸ | FAAH | O00519 | 2/20 | 0.37 |
| ▸ | BCHE | P06276 | 2/20 | 0.37 |
| ▸ | ACHE | P22303 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | USP5 | P45974 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL493466 | 0.86 | LMNA (0.39) | EPHX2ACLYFAAHBCHEACHE | |
| SCHEMBL492460 | 0.84 | KMT2A (0.40) | TRPV4EPHX2ACLYFAAHBCHE | |
| SCHEMBL492952 | 0.83 | TDP1 (0.42) | TRPV4ACLYFAAHBCHEACHE | |
| SCHEMBL493760 | 0.81 | PKM (0.37) | EPHX2ACLYTDP1SMN1; SMN2ATM | |
| SCHEMBL3660998 | 0.81 | ALDH1A1 (0.40) | EPHX2SMN1; SMN2 | |
| SCHEMBL493220 | 0.79 | TRPV4 (0.40) | TRPV4EPHX2CYP2C9CNR2SMN1; SMN2 | |
| SCHEMBL492756 | 0.79 | TRPV4 (0.39) | TRPV4EPHX2FAAHBCHEACHE | |
| SCHEMBL493066 | 0.77 | RAB9A (0.39) | TDP1TP53SMN1; SMN2ATM | |
| SCHEMBL5093760 | 0.74 | TRPV4 (0.52) | TRPV4EPHX2ACLYUSP5SMN1; SMN2 | |
| SCHEMBL492964 | 0.73 | ALDH1A1 (0.36) | TRPV4EPHX2ACHETDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | claimed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | claimed |
| EP-2139851-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008131946-A2 | SUBSTITUTED AMIDE DERIVATIVES | Grünenthal GmbH (DE) | 2008-11-06 | — | — | WO | disclosed |