Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A5 | Q9Y345 | 5/20 | 0.42 |
| ▸ | PRKAA2 | P54646 | 7/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.39 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.39 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.38 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.38 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.38 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.38 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.38 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3667019 | 0.91 | PRKAA2 (0.49) | SLC6A5PRKAA2PRKAB2PRKAG1PRKAA1 | |
| SCHEMBL3664555 | 0.90 | MEN1 (0.40) | SLC6A5DRD4DRD2RORCHIF1A | |
| SCHEMBL651761 | 0.88 | SLC6A5 (0.55) | SLC6A5PRKAA2DRD4DRD2HPGDS | |
| SCHEMBL3666588 | 0.87 | SSTR5 (0.42) | SLC6A5PRKAA2DRD4DRD2RORC | |
| SCHEMBL3662737 | 0.85 | MDM2 (0.41) | SLC6A5PRKAA2DRD4DRD2MDM2 | |
| SCHEMBL4441003 | 0.85 | DRD4 (0.43) | SLC6A5DRD4DRD2KMT2A | |
| SCHEMBL3664571 | 0.84 | USP30 (0.39) | — | |
| SCHEMBL3668637 | 0.84 | PRKAA2 (0.43) | SLC6A5PRKAA2DRD4DRD2PRKAB2 | |
| SCHEMBL3660163 | 0.84 | F10 (0.39) | SLC6A5PRKAA2DRD4RORCMDM2 | |
| SCHEMBL3665131 | 0.82 | PRKAA2 (0.43) | SLC6A5PRKAA2DRD4PRKAB2PRKAG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |