Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | SLC6A5 | Q9Y345 | 5/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3668637 | 0.94 | PRKAA2 (0.43) | MEN1KMT2ADRD4SLC6A5F10 | |
| SCHEMBL3665131 | 0.92 | PRKAA2 (0.43) | DRD4SLC6A5F10RORC | |
| SCHEMBL3661407 | 0.90 | SLC6A5 (0.42) | KMT2ADRD4SLC6A5MDM2DRD2 | |
| SCHEMBL4441003 | 0.88 | DRD4 (0.43) | KMT2ADRD4SLC6A5F10DRD2 | |
| SCHEMBL647123 | 0.88 | DRD4 (0.53) | DRD4SLC6A5SSTR5DRD2HTR2A | |
| SCHEMBL3660163 | 0.87 | F10 (0.39) | DRD4SLC6A5F10MDM2RORC | |
| SCHEMBL3666588 | 0.87 | SSTR5 (0.42) | DRD4SLC6A5F10SSTR5DRD2 | |
| SCHEMBL3662737 | 0.85 | MDM2 (0.41) | DRD4SLC6A5F10MDM2DRD2 | |
| SCHEMBL647932 | 0.82 | DRD4 (0.53) | DRD4SLC6A5SSTR5 | |
| SCHEMBL3667429 | 0.81 | SLC6A4 (0.40) | DRD4SLC6A5F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |