Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 3/20 | 0.38 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.36 |
| ▸ | F2R | P25116 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647173 | 0.88 | PRKAA2 (0.52) | DRD4PRKAA2SLC6A5CHRM2DRD2 | |
| SCHEMBL3664555 | 0.85 | MEN1 (0.40) | MDM2DRD4F10SLC6A5DRD2 | |
| SCHEMBL3661407 | 0.85 | SLC6A5 (0.42) | MDM2DRD4PRKAA2SLC6A5DRD2 | |
| SCHEMBL4441003 | 0.85 | DRD4 (0.43) | DRD4F10SLC6A5DRD2 | |
| SCHEMBL3660163 | 0.85 | F10 (0.39) | MDM2DRD4PRKAA2F10SLC6A5 | |
| SCHEMBL3798034 | 0.83 | SLC6A5 (0.50) | PRKAA2SLC6A5 | |
| SCHEMBL3666588 | 0.82 | SSTR5 (0.42) | DRD4PRKAA2F10SLC6A5DRD2 | |
| SCHEMBL3666339 | 0.82 | SLC6A4 (0.40) | DRD4PRKAA2F10SLC6A5DRD2 | |
| SCHEMBL3667429 | 0.81 | SLC6A4 (0.40) | DRD4PRKAA2F10SLC6A5 | |
| SCHEMBL3663620 | 0.81 | UTS2R (0.41) | DRD4F10SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2231600-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | Rigel Pharmaceuticals, Inc. (US) | 2010-09-29 | — | — | EP | claimed |
| WO-2009065131-A1 | CARBOXAMIDE, SULFONAMIDE AND AMINE COMPOUNDS FOR METABOLIC DISORDERS | RIGEL PHARMACEUTICALS, INC. (US) | 2009-05-22 | — | — | WO | claimed |