SCHEMBL3662258

SCHEMBL3662258

NC(=O)N(c1cccnc1)[C@@H]1CCNC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 4/20 0.44
SLC6A4 P31645 4/20 0.44
SLC6A3 Q01959 4/20 0.44
KCNH2 Q12809 2/20 0.44
CYP2D6 P10635 1/20 0.43
MKNK1 Q9BUB5 2/20 0.42
MKNK2 Q9HBH9 2/20 0.42
CHRNB2 P17787 5/20 0.41
CHRNA4 P43681 5/20 0.41
CHEK1 O14757 2/20 0.38
CDK2AP1 O14519 1/20 0.38
CHRNB4 P30926 2/20 0.38
CHRNA3 P32297 2/20 0.38
CHRM3 P20309 2/20 0.38
CYP3A4 P08684 1/20 0.37
CCNA2 P20248 1/20 0.37
CDK2 P24941 1/20 0.37
CHRM2 P08172 1/20 0.37
CHRM1 P11229 1/20 0.37
F7 P08709 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27979356 0.83 SLC6A2 (0.60) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL27564720 0.81 POLB (0.45) MKNK1MKNK2CHRM3
SCHEMBL6621005 0.74 SLC6A4 (0.49) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL30502020 0.73 GPR119 (0.40) SLC6A2SLC6A4SLC6A3MKNK1MKNK2
SCHEMBL14349560 0.73 CHRM3 (0.51) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL26133487 0.72 MKNK1 (0.35) MKNK1MKNK2CHRM3CYP3A4F7
Trifluoroacetic Acid SCHEMBL21222891 0.72 OPRM1 (0.47) SLC6A2SLC6A4SLC6A3KCNH2CHRNA4
SCHEMBL14882112 0.71 CHRM3 (0.51) CHRM3CYP3A4
SCHEMBL4244760 0.71 OPRM1 (0.47) SLC6A2SLC6A4SLC6A3KCNH2CYP2D6
SCHEMBL14349504 0.70 TRPM8 (0.50) SLC6A2SLC6A4SLC6A3CYP2D6CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2211865-A2 COMBINATION COMPRISING PURINE DERIVATIVES AND OTHER COMPOUNDS AND THE USE THEREOF FOR THE TREATMENT OF INFLAMMATORY AND OBSTRUCTIVE AIRWAY DISEASES Novartis AG (CH) 2010-08-04 EP disclosed
WO-2009050198-A2 COMBINATION COMPRISING PURINE DERIVATIVES AND OTHER COMPOUNDS AND THE USE THEREOF FOR THE TREATMENT OF INFLAMMATORY AND OBSTRUCTIVE AIRWAY DISEASES NOVARTIS AG (CH) 2009-04-23 WO disclosed
EP-2013211-A2 PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS Novartis AG (CH) 2009-01-14 EP disclosed
WO-2007121920-A2 PURINE DERIVATIVES FOR USE AS ADENOSIN A2A RECEPTOR AGONISTS NOVARTIS AG (CH) 2007-11-01 WO disclosed