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Histidine

Histidine

SCHEMBL3663298

CC(C)C[C@H](N)C(=O)OC[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.C[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)OC(=O)[C@@H](N)Cc1ccc(OC(=O)[C@@H]2CCCN2)cc1

nearest known ligand 0.33

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SSTR1SSTR2SSTR3SSTR5

The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ REN P00797 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Histidine SCHEMBL1896523 0.95 REN (0.32) REN
Arginine SCHEMBL6868910 0.83 APLNR (0.33) —
Asparagine SCHEMBL3252545 0.82 REN (0.30) REN
Glutamine SCHEMBL294952 0.79 REN (0.35) REN
Histidine SCHEMBL9538044 0.78 CRHR1 (0.34) REN
Phenylalanine SCHEMBL6387319 0.78 REN (0.34) REN
Phenylalanine SCHEMBL9617522 0.78 REN (0.37) REN
Proline SCHEMBL18075887 0.77 REN (0.31) REN
Phenylalanine SCHEMBL1585346 0.77 TUBB4A (0.33) —
Phenylalanine SCHEMBL8314461 0.77 APLNR (0.33) REN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2980217-A1 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS XOMA Technology Ltd. (US) 2016-02-03 — — EP disclosed
EP-2242843-B1 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS XOMA TECHNOLOGY LTD (US) 2015-05-27 — — EP disclosed
EP-2242843-A1 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS XOMA Technology Ltd. (US) 2010-10-27 — — EP disclosed
WO-2009088933-A1 METHODS AND MATERIALS FOR TARGETED MUTAGENESIS XOMA TECHNOLOGY LTD. (US) 2009-07-16 — — WO disclosed