Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLS | O94925 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.36 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.35 |
| ▸ | PIP5K1C | O60331 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | PIP5K1B | O14986 | 1/20 | 0.35 |
| ▸ | PIP5K1A | Q99755 | 1/20 | 0.35 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.35 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13702331 | 0.82 | HTR1A (0.41) | GLSHTR1ADRD2DRD4ITGB1 | |
| SCHEMBL47362 | 0.82 | GLS (0.40) | GLSHTR1ADRD2DRD4ITGB1 | |
| SCHEMBL25853714 | 0.80 | HTR1A (0.38) | GLSHTR1ADRD2DRD4ITGB1 | |
| SCHEMBL20928257 | 0.79 | CHRNB2 (0.47) | GLSHTR1ADRD2DRD4EPHX1 | |
| SCHEMBL25660845 | 0.78 | HTR1A (0.41) | GLSHTR1ADRD2DRD4MAPK10 | |
| SCHEMBL6313794 | 0.78 | HTR1A (0.41) | GLSHTR1ADRD2DRD4 | |
| SCHEMBL6240462 | 0.77 | — | — | |
| SCHEMBL13812593 | 0.77 | EPHX1 (0.66) | EPHX1 | |
| SCHEMBL29306574 | 0.77 | NAAA (0.53) | HTR1ADRD2DRD4 | |
| SCHEMBL28361513 | 0.75 | SMN1; SMN2 (0.45) | GLSHTR1ADRD2DRD4ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2227482-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | Pharmasset, Inc. (US) | 2010-09-15 | — | — | EP | claimed |
| WO-2009067409-A1 | 2',4'-SUBSTITUTED NUCLEOSIDES AS ANTIVIRAL AGENTS | PHARMASSET, INC. (US) | 2009-05-28 | — | — | WO | claimed |