Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1
The experimentally established mechanism targets of Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30214 | 0.90 | TGFBR1 (0.44) | TGFBR1TSHRRXFP1KDM4EALDH1A1 | |
| SCHEMBL9067167 | 0.75 | LMNA (0.35) | TSHR | |
| Acrylic Acid SCHEMBL2732803 | 0.75 | TSHR (0.50) | TGFBR1TP53TSHRRXFP1KDM4E | |
| SCHEMBL3388819 | 0.74 | TGFBR1 (0.44) | TGFBR1TSHRRXFP1KDM4EALDH1A1 | |
| SCHEMBL366543 | 0.73 | TGFBR1 (0.37) | TGFBR1TSHRRXFP1ALDH1A1 | |
| SCHEMBL472271 | 0.71 | TGFBR1 (0.55) | TGFBR1TP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL8518825 | 0.71 | TGFBR1 (0.55) | TGFBR1TP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL10626914 | 0.71 | TSHR (0.39) | TP53TSHR | |
| SCHEMBL149929 | 0.71 | TGFBR1 (0.55) | TGFBR1TP53RXFP1KDM4EALDH1A1 | |
| SCHEMBL865671 | 0.71 | TGFBR1 (0.55) | TGFBR1TP53RXFP1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110220-B2 | Temperature sensitive polymers | UNIVERSITEIT UTRECHT (NL) | 2012-02-07 | — | — | US | disclosed |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2012-01-19 | — | — | US | disclosed |
| EP-1776400-B1 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT VAN UTRECHT (NL) | 2009-12-23 | — | — | EP | disclosed |
| US-20080050435-A1 | Temperature Sensitive Polymers | CRISTAL DELIVERY B.V. (NL) | 2008-02-28 | — | — | US | disclosed |
| EP-1776400-A2 | TEMPERATURE SENSITIVE POLYMERS | Universiteit van Utrecht (NL) | 2007-04-25 | — | — | EP | disclosed |
| WO-2005087825-A2 | TEMPERATURE SENSITIVE POLYMERS | UNIVERSITEIT UTRECHT (NL) | 2005-09-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080050435-A1 | Temperature Sensitive Polymers | LCT, LDHB, LDHA | TGFBR1 4008/4885TP53 1460/4885TSHR 4210/4885 |
| US-20120015034-A1 | TEMPERATURE SENSITIVE POLYMERS | LCT, LDHA, LDHB | TGFBR1 4012/4885TP53 1519/4885TSHR 4451/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.