Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.43 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | GOPC | Q9HD26 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KCNA5 | P22460 | 3/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3674930 | 0.85 | KCNA5 (0.45) | SMN1; SMN2ALDH1A1KCNA5KDM4ECYP3A4 | |
| SCHEMBL3674513 | 0.83 | P2RX7 (0.42) | SLC6A3SLC6A2SLC6A4ALDH1A1KCNA5 | |
| SCHEMBL3414027 | 0.78 | CFB (0.39) | SLC6A2SLC6A4OPRM1OPRD1ADRA2A | |
| SCHEMBL3415731 | 0.73 | TAAR1 (0.43) | SLC6A3SLC6A2SLC6A4KCNH2CYP3A4 | |
| SCHEMBL1156686 | 0.73 | CYP1A2 (0.56) | CFTRGOPCSMN1; SMN2KDM4ECYP3A4 | |
| SCHEMBL3673071 | 0.72 | ADRA2A (0.47) | KCNA5ADRA2A | |
| SCHEMBL3411857 | 0.72 | CFB (0.36) | ADRA2AADRA2BADRA2C | |
| SCHEMBL3415420 | 0.71 | ADRA2A (0.41) | SLC6A3SLC6A2SLC6A4MAPTOPRM1 | |
| SCHEMBL9129451 | 0.70 | SLC6A3 (0.53) | SLC6A3CFTRGOPCSLC6A2SLC6A4 | |
| SCHEMBL3671371 | 0.68 | KCNA5 (0.33) | KCNA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2242753-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-10-27 | — | — | EP | disclosed |
| EP-2240468-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009091760-A1 | OXAZOLIDINE AND THIAZOLIDINE SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-07-23 | — | — | WO | disclosed |
| WO-2009091759-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-07-23 | — | — | WO | disclosed |