Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.42 |
| ▸ | KCNA5 | P22460 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 4/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3673459 | 0.86 | P2RX7 (0.41) | P2RX7 | |
| SCHEMBL3669311 | 0.85 | CFB (0.36) | P2RX7 | |
| SCHEMBL3666286 | 0.83 | SLC6A3 (0.43) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3468595 | 0.81 | HSD17B10 (0.48) | P2RX7KCNA5KCNH2SLC6A2SLC6A4 | |
| SCHEMBL3411857 | 0.78 | CFB (0.36) | P2RX7 | |
| SCHEMBL3674930 | 0.77 | KCNA5 (0.45) | KCNA5CYP2D6ALDH1A1THRBMAPT | |
| SCHEMBL1156800 | 0.74 | DRD2 (0.37) | P2RX7KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3671371 | 0.74 | KCNA5 (0.33) | KCNA5POLB | |
| SCHEMBL2472266 | 0.72 | KCNA5 (0.47) | KCNA5KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3671172 | 0.72 | CFB (0.36) | SLC6A2SLC6A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2240468-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2010-10-20 | — | — | EP | disclosed |
| WO-2009091759-A1 | SELECTIVE SUBTYPE ALPHA 2 ADRENERGIC AGENTS AND METHODS FOR USE THEREOF | ALLERGAN, INC. (US) | 2009-07-23 | — | — | WO | disclosed |