SCHEMBL3667484

SCHEMBL3667484

O=C1CNCCN1c1ccc(Br)cc1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 2/20 0.49
SLC6A4 P31645 2/20 0.49
SLC6A3 Q01959 2/20 0.49
MAPKAPK2 P49137 1/20 0.42
RXFP1 Q9HBX9 1/20 0.39
IDO1 P14902 1/20 0.39
FAAH O00519 1/20 0.37
MGLL Q99685 1/20 0.37
MMP13 P45452 1/20 0.36
WEE1 P30291 1/20 0.36
PTGS2 P35354 1/20 0.36
MAPT P10636 1/20 0.35
MAP4K1 Q92918 1/20 0.35
CTSG P08311 1/20 0.35
CMA1 P23946 1/20 0.35
MMP2 P08253 1/20 0.35
MMP9 P14780 1/20 0.35
CHRNB2 P17787 1/20 0.34
CHRNA4 P43681 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3656969 0.84 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3MAPKAPK2MGLL
SCHEMBL4396319 0.84 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3MAPKAPK2WEE1
SCHEMBL85663 0.84 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3MAPKAPK2WEE1
SCHEMBL655077 0.82 SLC6A2 (0.56) SLC6A2SLC6A4SLC6A3MAPKAPK2WEE1
Hydrochloric Acid SCHEMBL1583516 0.82 SLC6A2 (0.51) SLC6A2SLC6A4SLC6A3MAPKAPK2MAPT
SCHEMBL1584076 0.82 SLC6A2 (0.49) SLC6A2SLC6A4SLC6A3MAPKAPK2MGLL
SCHEMBL8286227 0.82 ADRB1 (0.52) SLC6A2SLC6A4SLC6A3MAPKAPK2MAPT
SCHEMBL532873 0.81 NPC1 (0.50) SLC6A2SLC6A4SLC6A3MAPKAPK2PTGS2
Hydrochloric Acid SCHEMBL1583739 0.81 SLC6A2 (0.50) SLC6A2SLC6A4SLC6A3MAPKAPK2MGLL
Hydrochloric Acid SCHEMBL3657338 0.81 SLC6A2 (0.57) SLC6A2SLC6A4SLC6A3MAPKAPK2WEE1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4648853-A1 TARGETED DEGRADATION OF VAV1 Monte Rosa Therapeutics AG (CH) 2025-11-19 EP disclosed
US-12384778-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2025-08-12 US disclosed
US-20250205219-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS AG (CH) 2025-06-26 US disclosed
US-12257247-B2 Targeted degradation of VAV1 MONTE ROSA THERAPEUTICS AG (CH) 2025-03-25 US disclosed
US-20240285604-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS AG (CH) 2024-08-29 US disclosed
US-20240287059-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2024-08-29 US disclosed
WO-2024151547-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS, INC. (US) 2024-07-18 WO disclosed
WO-2024151547-A1 TARGETED DEGRADATION OF VAV1 MONTE ROSA THERAPEUTICS, INC. (US) 2024-07-18 WO disclosed
US-11795166-B2 Pyrazolopyridine compounds and uses thereof INCYTE CORPORATION (US) 2023-10-24 US disclosed
CN-115819417-A Pyrazolopyridine derivatives as HPK1 modulators and their use for the treatment of cancer 因赛特公司 2023-03-21 CN disclosed
US-20180072720-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF INCYTE CORPORATION 2018-03-15 US disclosed
WO-2018049200-A1 PYRAZOLOPYRIDINE DERIVATIVES AS HPK1 MODULATORS AND USES THEREOF FOR THE TREATMENT OF CANCER INCYTE CORPORATION (US) 2018-03-15 WO disclosed
US-9745311-B2 Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors INCYTE CORPORATION (US) 2017-08-29 US disclosed
US-20160280713-A1 PYRAZINE DERIVATIVES AS FGFR INHIBITORS INCYTE CORPORATION 2016-09-29 US disclosed
US-9388185-B2 Substituted pyrrolo[2,3-b]pyrazines as FGFR inhibitors INCYTE HOLDINGS CORPORATION (US) 2016-07-12 US disclosed
US-20140045814-A1 PYRAZINE DERIVATIVES AS FGFR INHIBITORS INCYTE CORPORATION (US) 2014-02-13 US disclosed
WO-2014026125-A1 PYRAZINE DERIVATIVES AS FGFR INHIBITORS INCYTE CORPORATION (US) 2014-02-13 WO disclosed
EP-2242746-A1 HETEROCYCLICALLY-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF Sanofi-Aventis (FR) 2010-10-27 EP disclosed
WO-2009098000-A1 HETEROCYCLICALLY-SUBSTITUTED IMIDAZOLIDINE-2,4-DIONES, METHOD FOR THE PRODUCTION THEREOF, MEDICAMENTS CONTAINING SAID COMPOUNDS AND USE THEREOF SANOFI-AVENTIS (FR) 2009-08-13 WO disclosed
WO-2009050236-A1 NOVEL PIPERAZINO-DIHYDROTHIENOPYRIMIDINE DERIVATIVES BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-04-23 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12384778-B2 Pyrazolopyridine compounds and uses thereof PDXK, PCK1, PGK1 SLC6A2 4345/4885SLC6A4 3975/4885SLC6A3 4076/4885
US-11795166-B2 Pyrazolopyridine compounds and uses thereof PDXK, PCK1, PGK1 SLC6A2 4345/4885SLC6A4 3975/4885SLC6A3 4076/4885
US-20180072720-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF PDXK, PCK1, PGK1 SLC6A2 4345/4885SLC6A4 3975/4885SLC6A3 4076/4885
US-20240285604-A1 TARGETED DEGRADATION OF VAV1 VAV1, KRAS, CBL SLC6A2 4100/4885SLC6A4 4304/4885SLC6A3 4079/4885
US-12257247-B2 Targeted degradation of VAV1 VAV1, KRAS, CBL SLC6A2 4100/4885SLC6A4 4304/4885SLC6A3 4079/4885
US-20160280713-A1 PYRAZINE DERIVATIVES AS FGFR INHIBITORS FGFR1, FGFR2, FGFR3 SLC6A2 4844/4885SLC6A4 4760/4885SLC6A3 4613/4885
US-20250205219-A1 TARGETED DEGRADATION OF VAV1 VAV1, KRAS, CBL SLC6A2 4100/4885SLC6A4 4304/4885SLC6A3 4079/4885
US-20240287059-A1 PYRAZOLOPYRIDINE COMPOUNDS AND USES THEREOF PDXK, PCK1, PGK1 SLC6A2 4345/4885SLC6A4 3975/4885SLC6A3 4076/4885
US-20140045814-A1 PYRAZINE DERIVATIVES AS FGFR INHIBITORS FGFR1, FGFR2, FGFR3 SLC6A2 4844/4885SLC6A4 4760/4885SLC6A3 4613/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.