Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.56 |
| ▸ | HTR3B | O95264 | 1/20 | 0.56 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.56 |
| ▸ | HTR3A | P46098 | 1/20 | 0.56 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.56 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28599511 | 0.84 | HTR3E (0.73) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL29656856 | 0.84 | HTR3E (0.73) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL9671046 | 0.82 | HTR3E (0.56) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL2359934 | 0.81 | ADRB1 (0.59) | ADRB1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL28432321 | 0.79 | MAPT (0.64) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL8984715 | 0.79 | ADRB1 (0.52) | L3MBTL1ADRB1LMNASMN1; SMN2MAPT | |
| SCHEMBL15887431 | 0.79 | HTR3E (0.61) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL3047529 | 0.78 | L3MBTL1 (0.53) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL14362730 | 0.77 | HTR3E (0.63) | L3MBTL1HTR3EHTR3BADRB1HTR3A | |
| SCHEMBL6153220 | 0.77 | ALDH1A1 (0.66) | L3MBTL1HTR3EHTR3BADRB1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2146990-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES AND TRIAZOLOPYRIMIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | Sanofi-Aventis (FR) | 2010-01-27 | — | — | EP | disclosed |
| WO-2008145839-A1 | TRIAZOLOPYRIDINE CARBOXAMIDE DERIVATIVES AND TRIAZOLOPYRIMIDINE CARBOXAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2008-12-04 | — | — | WO | disclosed |