Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | SRC | P12931 | 3/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL367569 | 0.91 | SRC (0.46) | EGFRKDM4ESRCALDH1A1HPGD | |
| SCHEMBL365935 | 0.89 | KDM4E (0.47) | EGFRKDM4ESRCAGTR1ALDH1A1 | |
| SCHEMBL367330 | 0.87 | EGFR (0.46) | EGFRKDM4ESRCALDH1A1HPGD | |
| Potassium Ion SCHEMBL364867 | 0.85 | ALDH1A1 (0.40) | EGFRKDM4ESRCALDH1A1HPGD | |
| SCHEMBL366811 | 0.85 | EGFR (0.44) | EGFRKDM4ESRCAGTR1ALDH1A1 | |
| SCHEMBL366442 | 0.84 | ALDH1A1 (0.42) | EGFRKDM4ESRCALDH1A1HPGD | |
| SCHEMBL364281 | 0.84 | NR4A2 (0.48) | EGFRKDM4ESRCALDH1A1POLB | |
| SCHEMBL367205 | 0.84 | EGFR (0.45) | EGFRKDM4ESRCAGTR1ALDH1A1 | |
| SCHEMBL366371 | 0.84 | EGFR (0.45) | EGFRKDM4ESRCAGTR1ALDH1A1 | |
| SCHEMBL364389 | 0.83 | ALDH1A1 (0.48) | EGFRKDM4ESRCALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007007-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |