Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BRD2 | P25440 | 1/20 | 0.43 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.43 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL364265 | 0.86 | NR4A2 (0.46) | EGFRSRCNR4A2KDM4EPOLB | |
| SCHEMBL365935 | 0.85 | KDM4E (0.47) | EGFRSRCKDM4EL3MBTL1AGTR1 | |
| SCHEMBL366784 | 0.84 | SCN9A (0.50) | EGFRSRCAGTR1 | |
| SCHEMBL366876 | 0.84 | EGFR (0.44) | EGFRSRCKDM4EAGTR1POLB | |
| SCHEMBL365909 | 0.82 | LMNA (0.45) | EGFRSRCBRD4KDM4EL3MBTL1 | |
| SCHEMBL365666 | 0.81 | HPGD (0.52) | EGFRSRCBRD4KDM4EALDH1A1 | |
| SCHEMBL366811 | 0.81 | EGFR (0.44) | EGFRSRCKDM4EL3MBTL1AGTR1 | |
| SCHEMBL367205 | 0.81 | EGFR (0.45) | EGFRSRCKDM4EAGTR1POLB | |
| SCHEMBL366536 | 0.80 | EGFR (0.53) | EGFRSRCKDM4EALDH1A1HPGD | |
| SCHEMBL366370 | 0.78 | EGFR (0.43) | EGFRSRCKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |