Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365250 | 0.85 | NR4A2 (0.45) | EGFRSRCKDM4EALDH1A1MEN1 | |
| SCHEMBL365935 | 0.85 | KDM4E (0.47) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL366876 | 0.84 | EGFR (0.44) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL366811 | 0.81 | EGFR (0.44) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL366371 | 0.81 | EGFR (0.45) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL365388 | 0.80 | ALDH1A1 (0.49) | EGFRSRCKDM4EALDH1A1HPGD | |
| SCHEMBL366790 | 0.79 | EGFR (0.41) | EGFRSRCKDM4EAGTR1ALDH1A1 | |
| SCHEMBL367204 | 0.78 | RORC (0.43) | EGFRSRCKDM4EALDH1A1MEN1 | |
| SCHEMBL366536 | 0.78 | EGFR (0.53) | EGFRSRCKDM4EALDH1A1HPGD | |
| SCHEMBL365912 | 0.78 | CES1 (0.45) | EGFRSRCKDM4EAGTR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |