Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 2/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.35 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3669027 | 1.00 | BCHE (0.36) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL15442718 | 1.00 | BCHE (0.36) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL6690567 | 0.89 | BCHE (0.38) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL6671393 | 0.84 | SIRT1 (0.34) | BCHEACHESIRT1MCL1MAPT | |
| SCHEMBL5620552 | 0.83 | SIRT1 (0.41) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL5523109 | 0.83 | SIRT1 (0.41) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL5265253 | 0.82 | SIRT1 (0.35) | BCHEACHESIRT1MCL1MAOB | |
| SCHEMBL5267655 | 0.82 | SIRT1 (0.35) | BCHEACHESIRT1MCL1MAOB | |
| SCHEMBL4620243 | 0.79 | SIRT1 (0.38) | BCHEACHESIRT1MCL1PIN1 | |
| SCHEMBL5268318 | 0.79 | PIN1 (0.38) | BCHEACHEPIN1MAPTMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100048920-A1 | Preparation of (+)-Catechin, (-)-Epicatechin, (-)-Catechin, and (+)-Epicatechin and Their 5,7,3',4'-Tetra-O-Benzyl Analogues | MARS, INCORPORATED (US) | 2010-02-25 | — | — | US | claimed |
| US-20080306286-A1 | Isolation, Purification and Synthesis of Procyanidin B2 and Uses Thereof | PROTAMED, INC. | 2008-12-11 | — | — | US | claimed |
| EP-1921076-A1 | systhesis of procyanidin B2 | Proteotech Inc. (US) | 2008-05-14 | — | — | EP | claimed |
| EP-1896443-A1 | PREPARATION OF (+)-CATECHIN, (-)-EPICATECHIN, (-)-CATECHIN, (+)-EPICATECHIN, AND THEIR 5,7,3',4'-TETRA-O-BENZYL ANALOGUES | MARS, INCORPORATED (US) | 2008-03-12 | — | — | EP | claimed |
| EP-1896444-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4 , 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES | MARS, INCORPORATED (US) | 2008-03-12 | — | — | EP | claimed |
| US-20070276147-A1 | Synthesis of Oligomeric Epicatechin- and Catechin-Derived Procyanidins | KOZIKOWSKI ALAN P | 2007-11-29 | — | — | US | claimed |
| EP-1317437-B1 | SYNTHESIS OF 4-ALPHA-ARYLEPICATECHINS | MARS INC (US) | 2007-10-03 | — | — | EP | claimed |
| US-7268240-B2 | Synthetic methods for polyphenols | MARS, INC. | 2007-09-11 | — | — | US | claimed |
| US-7244855-B2 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins | MARS, INC. | 2007-07-17 | — | — | US | claimed |
| WO-2007005248-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF PROTECTED -(+)-CATECHIN AND (-)-EPICATECHIN NOMOMERS, FOR COUPLING THE PROTECTED MONOMERS WITH AN ACTIVATED, PROTECTED EPICATECHIN MONOMER, AND FOR THE PREPARATION OF EPICATECHIN-(4β, 8)-EPICATECHIN OR -CATECHIN DIMERS AND THEIR DIGALLATES | MARS, INCORPORATED (US) | 2007-01-11 | — | — | WO | claimed |
| US-7067679-B2 | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest | MARS, INC. | 2006-06-27 | — | — | US | claimed |
| EP-1554270-A2 | ISOLATION, PURIFICATION AND SYNTHESIS OF PROCYANIDIN B2 AND USES THEREOF | Proteotech, Inc. (US) | 2005-07-20 | — | — | EP | claimed |
| US-20050020512-A1 | Synthesis of oligomeric epicatechin and catechin-derived procyanidins | MARS, INCORPORATED | 2005-01-27 | — | — | US | claimed |
| US-20040116718-A1 | Synthesis of dimeric, trimeric, tetrameric pentameric, and higher oligomeric epicatechin-derived procyanidins having 4beta,8-interflavan linkages and their use to inhibit cancer cell growth through cell cycle arrest | MARS, INC. | 2004-06-17 | — | — | US | claimed |
| WO-2004033448-A2 | ISOLATION, PURIFICATION AND SYNTHESIS OF PROCYANIDIN B2 AND USES THEREOF | PROTEOTECH, INC. (US) | 2004-04-22 | — | — | WO | claimed |
| JP-2004508362-A | — | — | 2004-03-18 | — | — | JP | claimed |
| EP-1317437-A2 | SYNTHESIS OF 4-ALPHA-ARYLEPICATECHINS | Mars Incorporated (US) | 2003-06-11 | — | — | EP | claimed |
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | MARS INCORPORATED | 2003-05-29 | — | — | US | claimed |
| US-6476241-B1 | Synthesis of 4α-arylepicatechins | MARS INCORPORATED | 2002-11-05 | — | — | US | claimed |
| WO-2002020506-A2 | SYNTHESIS OF 4α-ARYLEPICATECHINS | MARS, INCORPORATED (US) | 2002-03-14 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030100775-A1 | Synthesis of 4alpha-arylepicatechins | FABP4, TEAD4, FABP7 | BCHE 1134/4885ACHE 3773/4885SIRT1 1320/4885 |
| US-20100048920-A1 | Preparation of (+)-Catechin, (-)-Epicatechin, (-)-Catechin, and (+)-Epicatechin and Their 5,7,3',4'-Tetra-O-Benzyl Analogues | HAAO, TES, HPD | BCHE 89/4885ACHE 997/4885SIRT1 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.