SCHEMBL3671356

SCHEMBL3671356

FC(F)(F)C(F)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 9/20 0.45
LMNA P02545 1/20 0.44
CYP2A6 P11509 1/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
TSHR P16473 1/20 0.44
MAPK1 P28482 1/20 0.44
HIF1A Q16665 1/20 0.44
MIF P14174 1/20 0.37
IDO1 P14902 1/20 0.35
AHR P35869 1/20 0.34
PDK1 Q15118 1/20 0.34
PDK2 Q15119 1/20 0.34
PDK3 Q15120 1/20 0.34
PDK4 Q16654 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL502544 0.84 CYP19A1 (0.42) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL2360480 0.82 ALDH1A1 (0.37) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL5350641 0.78 CYP19A1 (0.45) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL608968 0.78 ESR1 (0.56) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL196588 0.77 CYP19A1 (0.55) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL28777340 0.77 CYP19A1 (0.55) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL809832 0.77 LMNA (0.50) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL5401000 0.77 LMNA (0.50) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL3678693 0.76 TSHR (0.61) CYP19A1LMNACYP2A6MEN1KMT2A
SCHEMBL12869567 0.74 LMNA (0.47) CYP19A1LMNACYP2A6MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1329444-B1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORP (JP) 2010-05-05 EP disclosed
US-6933068-B2 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA (JP) 2005-08-23 US disclosed
US-6833426-B2 A proton-conductive membrane containing the sulfonic acid group-containing polyarylene (co)polymer JSR CORPORATION (JP) 2004-12-21 US disclosed
US-6794480-B2 POLYARYLENE-BASED COPOLYMER USEFUL AS PROTON-CONDUCTIVE MEMBRANE WHICH CAN BE USED AS ELECTRON FOR PRIMARY BATTERY, ELECTROLYTE FOR SECONDARY BATTERY, HIGH MOLECULAR SOLID ELECTROLYTE FOR FUEL CELL JSR CORPORATION (JP) 2004-09-21 US disclosed
US-20030173547-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR CORPORATION (JP) 2003-09-18 US disclosed
EP-1329444-A1 Halogenated aromatic compound, (co)polymer thereof, and proton-conductive membrane comprising same JSR Corporation (JP) 2003-07-23 EP disclosed
US-20020177656-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR CORPORATION (JP) 2002-11-28 US disclosed
US-20020172850-A1 Polymer electrolyte membrane and solid polymer electrolyte fuel cell using same HONDA GIKEN KOGYO KABUSHIKI KAISHA, JSR CORPORATION 2002-11-21 US disclosed
EP-1245554-A1 Monomer containing electron-withdrawing group and electron-donative group, and copolymer and proton-conductive membrane comprising same JSR Corporation (JP) 2002-10-02 EP disclosed