SCHEMBL502544

SCHEMBL502544

FC(F)(F)C(F)(F)C(F)(c1ccc(Cl)cc1)c1ccc(Cl)cc1

nearest known ligand 0.42

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 10/20 0.42
MEN1 O00255 1/20 0.41
KMT2A Q03164 1/20 0.41
TSHR P16473 1/20 0.41
MAPK1 P28482 1/20 0.41
HIF1A Q16665 1/20 0.41
LMNA P02545 1/20 0.40
CYP2A6 P11509 1/20 0.40
MIF P14174 1/20 0.34
PDK1 Q15118 1/20 0.32
PDK2 Q15119 1/20 0.32
PDK3 Q15120 1/20 0.32
PDK4 Q16654 1/20 0.32
AHR P35869 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3671356 0.84 CYP19A1 (0.45) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL28423412 0.77 KCNN4 (0.38) CYP19A1MEN1KMT2AMAPK1
SCHEMBL308187 0.75 KIF11 (0.50) MEN1KMT2ATSHRMAPK1HIF1A
SCHEMBL306439 0.75 ESR1 (0.58) MEN1KMT2ATSHRHIF1ALMNA
SCHEMBL608968 0.74 ESR1 (0.56) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL516478 0.74 TSHR (0.52) TSHRMAPK1
SCHEMBL5350641 0.74 CYP19A1 (0.45) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL5238555 0.74 CYP19A1 (0.45) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL809832 0.73 LMNA (0.50) CYP19A1MEN1KMT2ATSHRMAPK1
SCHEMBL196588 0.73 CYP19A1 (0.55) CYP19A1MEN1KMT2ATSHRMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111302944-B Preparation method of bis (3-amino-4-hydroxyphenyl) hexafluoropropane 上海如鲲新材料有限公司 2021-01-15 CN disclosed
CN-111302944-A Preparation method of bis (3-amino-4-hydroxyphenyl) hexafluoropropane 上海如鲲新材料有限公司 2020-06-19 CN disclosed
EP-2438106-B1 OLIGOMERS WITH DI-PHENYLETHYNYL ENDCAPS BOEING CO (US) 2015-03-11 EP disclosed
EP-2438106-A1 OLIGOMERS WITH DI-PHENYLETHYNYL ENDCAPS The Boeing Company (US) 2012-04-11 EP disclosed
US-8106142-B2 Polyacetylinic oligomers THE BOEING COMPANY (US) 2012-01-31 US disclosed
US-8063168-B2 Oligomers with di-phenylethynyl endcaps THE BOEING COMPANY (US) 2011-11-22 US disclosed
WO-2010141106-A1 OLIGOMERS WITH DI-PHENYLETHYNYL ENDCAPS THE BOEING COMPANY (US) 2010-12-09 WO disclosed
US-20100204485-A1 POLYACETYLINIC OLIGOMERS THE BOEING COMPANY 2010-08-12 US disclosed
US-20100204412-A1 OLIGOMERS WITH DI-PHENYLETHYNYL ENDCAPS THE BOEING COMPANY 2010-08-12 US disclosed
US-5071941-A Multidimensional ether sulfone oligomers THE BOEING COMPANY (US) 1991-12-10 US disclosed
US-4851501-A Polyethersulfone prepregs, composites, and blends THE BOEING COMPANY (US) 1989-07-25 US disclosed
US-4739030-A Difunctional end-cap monomers THE BOEING COMPANY (US) 1988-04-19 US disclosed
US-4536559-A Thermally stable polyimide polysulfone compositions for composite structures THE BOEING COMPANY (US) 1985-08-20 US disclosed
US-4476184-A CURABLE THERMOPLASTIC PREPRESS, OXYNADIMIDE SUBSTITUENTS THE BOEING COMPANY (US) 1984-10-09 US disclosed
US-4414269-A CONTAINING CONDENSATION PRODUCT OF AMINO-PHENOL AND ACID ANHYDRIDE, AN AROMATIC POLYOL, AND AROMATIC DIHALIDE TRW, INC. (US) 1983-11-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100204485-A1 POLYACETYLINIC OLIGOMERS AADAC, ACMSD, ECPAS CYP19A1 4671/4885MEN1 4503/4885KMT2A 1850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.