Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.68 |
| ▸ | AKR1C3 | P42330 | 7/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | FABP2 | P12104 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22404548 | 0.85 | EPHX1 (0.47) | PTGS2AKR1C3AKR1C2LMNAPPARG | |
| SCHEMBL11841738 | 0.83 | LMNA (0.57) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL11851177 | 0.81 | AKR1C3 (0.69) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL10981141 | 0.81 | PTGS2 (0.66) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL11846562 | 0.81 | PPARG (0.49) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL1072964 | 0.81 | AKR1C3 (0.69) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL30057689 | 0.81 | SLC1A3 (0.55) | PTGS2AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL29867575 | 0.81 | AKR1C3 (0.69) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL1211557 | 0.81 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1MEN1 | |
| SCHEMBL7826539 | 0.81 | PTGS2 (1.00) | PTGS2AKR1C3AKR1C2PTGS1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246800-A1 | BETA-AMINO ACID COMPOUNDS AS INTEGRIN ANTAGONISTS | Bayer Aktiengesellschaft (DE) | 2002-10-09 | — | — | EP | claimed |
| WO-2001047887-A1 | β-AMINO ACID COMPOUNDS AS INTEGRIN ANTAGONISTS | BAYER AKTIENGESELLSCHAFT (DE) | 2001-07-05 | — | — | WO | claimed |
| US-7812038-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS, INC. (US) | 2010-10-12 | — | — | US | disclosed |
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | BIEDIGER RONALD J | 2006-12-07 | — | — | US | disclosed |
| US-6972296-B2 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | ENCYSIVE PHARMACEUTICALS INC. (US) | 2005-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276476-A1 | Carboxylic acid derivatives that inhibit the binding of integrins to their receptors | VCAM1, ICAM1, ITGA1 | PTGS2 3523/4885AKR1C3 809/4885AKR1C2 844/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.