Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.32 |
| ▸ | GMNN | O75496 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CETP | P11597 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | UBE2N | P61088 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1404261 | 0.84 | LMNA (0.56) | LMNATSHRTDP1CYP2D6SPHK1 | |
| SCHEMBL9272640 | 0.83 | TSHR (0.44) | LMNATSHRTDP1 | |
| SCHEMBL17464910 | 0.82 | LMNA (0.64) | LMNATSHRTDP1CYP2D6SPHK1 | |
| SCHEMBL6436313 | 0.81 | LMNA (0.56) | LMNATSHRTDP1 | |
| SCHEMBL1614519 | 0.81 | TSHR (0.46) | LMNATSHRTDP1METAP1 | |
| SCHEMBL16207737 | 0.80 | TSHR (0.42) | LMNATSHRTDP1 | |
| SCHEMBL18961175 | 0.80 | LMNA (0.61) | LMNATSHRTDP1CYP2D6SPHK1 | |
| SCHEMBL13757121 | 0.80 | LMNA (0.61) | LMNATSHRTDP1CYP2D6SPHK1 | |
| SCHEMBL8757790 | 0.80 | LMNA (0.76) | LMNATSHRTDP1CYP2D6SPHK1 | |
| SCHEMBL5154336 | 0.78 | LMNA (0.65) | LMNATSHRTDP1CYP2D6SPHK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170298058-A1 | HETEROCYCLIC RING AND CARBOCYCLIC DERIVATIVE | SHIONOGI & CO (JP) | 2017-10-19 | — | — | US | disclosed |
| US-9550763-B2 | Heterocyclic ring and carbocyclic derivative | SHIONOGI & CO., LTD. (JP) | 2017-01-24 | — | — | US | disclosed |
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | SHIONOGI & CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2164629-A1 | PROCESS OF OXIDATIVE DEHYDROGENATION USING A BORIA-ALUMINA CATALYST | Saudi Basic Industries Corporation (SA) | 2010-03-24 | — | — | EP | disclosed |
| WO-2008141827-A1 | PROCESS OF OXIDATIVE DEHYDROGENATION USING A BORIA-ALUMINA CATALYST | SAUDI BASIC INDUSTRIES CORPORATION (SA) | 2008-11-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170298058-A1 | HETEROCYCLIC RING AND CARBOCYCLIC DERIVATIVE | P2RX3, P2RX7, P2RX2 | LMNA 3635/4885TSHR 737/4885TDP1 4738/4885 |
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | P2RX3, P2RX7, P2RX2 | LMNA 3635/4885TSHR 737/4885TDP1 4738/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.