Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL6142954 | 0.92 | ALDH1A1 (0.48) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL9389636 | 0.80 | RXFP1 (0.45) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL9390809 | 0.80 | RXFP1 (0.55) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL9385776 | 0.80 | TP53 (0.45) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL8980209 | 0.80 | RAB9A (0.44) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL31138864 | 0.80 | RXFP1 (0.58) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL339071 | 0.79 | POLB (0.38) | ALDH1A1MAPTKDM4EKMT2ANPSR1 | |
| SCHEMBL10743435 | 0.78 | TTR (0.44) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL22100515 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MAPTTP53RXFP1RAB9A | |
| SCHEMBL29640568 | 0.78 | RXFP1 (0.57) | ALDH1A1MAPTTP53RXFP1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 113 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220273608-A1 | Methods for Treating Bone-Related Disorders | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2022-09-01 | — | — | US | claimed |
| US-20190351055-A1 | Methods for Treating Bone-Related Disorders | UNIVERSITY OF BALTIMORE, MARYLAND (US) | 2019-11-21 | — | — | US | claimed |
| EP-3541474-A1 | METHODS FOR TREATING BONE-RELATED DISORDERS | University Of Maryland, Baltimore (US) | 2019-09-25 | — | — | EP | claimed |
| WO-2018094059-A1 | METHODS FOR TREATING BONE-RELATED DISORDERS | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2018-05-24 | — | — | WO | claimed |
| US-9511117-B2 | Treatment of muscular conditions and muscular dystrophies | UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2016-12-06 | — | — | US | claimed |
| US-9029394-B2 | 2-phenyl-4-quinolones as anticancer agents | CHINA MEDICAL UNIVERSITY (TW) | 2015-05-12 | — | — | US | claimed |
| US-20140256644-A1 | Treatment of Muscular Conditions and Muscular Dystrophies | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2014-09-11 | — | — | US | claimed |
| EP-2455369-B1 | Derivatives of 2-aryl-4-quinolones having an aminoalkyl group as anticancer agents | UNIV CHINA MEDICAL (TW) | 2014-09-03 | — | — | EP | claimed |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2013-09-26 | — | — | US | claimed |
| WO-2013078261-A1 | TREATMENT OF MUSCULAR CONDITIONS AND MUSCULAR DYSTROPHIES | THE UNIVERSITY OF MARYLAND, BALTIMORE (US) | 2013-05-30 | — | — | WO | claimed |
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2010-07-01 | — | — | US | claimed |
| CN-101583280-A | Novel hydrophilic derivatives of 2-aryl-4-quinolones as anticancer agents | UNIV CHINA MEDICAL (CN) | 2009-11-18 | — | — | CN | claimed |
| EP-2096924-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | China Medical University (TW) | 2009-09-09 | — | — | EP | claimed |
| WO-2008070176-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | CHINA MEDICAL UNIVERSITY (TW) | 2008-06-12 | — | — | WO | claimed |
| JP-2002522388-A | — | — | 2002-07-23 | — | — | JP | claimed |
| EP-1107759-A1 | PYRIDINONES FOR THE TREATMENT OF SEXUAL DYSFUNCTION | Basf Corporation (US) | 2001-06-20 | — | — | EP | claimed |
| WO-2000035865-A2 | TUBULIN-BINDING AGENTS | TULARIK INC. (US) | 2000-06-22 | — | — | WO | claimed |
| WO-2000007595-A1 | PYRIDINONES FOR THE TREATMENT OF SEXUAL DYSFUNCTION | BASF CORPORATION (US) | 2000-02-17 | — | — | WO | claimed |
| US-5571822-A | AMINO-2-PHENYL-4-QUINOLONE DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-11-05 | — | — | US | claimed |
| WO-1996010563-A1 | 2-ARYL-4-QUINOLONES AS ANTITUMOR COMPOUNDS | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-04-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168064-A1 | NOVEL HYDROPHILIC DERIVATIVES OF 2-ARYL-4-QUINOLONES AS ANTICANCER AGENTS | DHX30, SLC20A2, DDX20 | ALDH1A1 3130/4885MAPT 4187/4885TP53 279/4885 |
| US-20130252999-A1 | 2-PHENYL-4-QUINOLONES AS ANTICANCER AGENTS | PPIP5K2, DDX5, DHX30 | ALDH1A1 3490/4885MAPT 3843/4885TP53 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.