Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 14/20 | 0.72 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.59 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.55 |
| ▸ | TUBB | P07437 | 1/20 | 0.55 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.55 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.55 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.55 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.55 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.55 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.55 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.55 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.55 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.55 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.55 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.55 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.55 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.55 |
| ▸ | PARP1 | P09874 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29850802 | 1.00 | TYMS (0.72) | TYMSQTRT1TUBB4ATUBBTUBA3C | |
| SCHEMBL13102494 | 0.86 | TYMS (0.63) | TYMSQTRT1PARP1CYP1A2 | |
| SCHEMBL18735812 | 0.84 | TYMS (0.61) | TYMSQTRT1CYP1A2 | |
| SCHEMBL6653074 | 0.84 | TYMS (1.00) | TYMS | |
| SCHEMBL4311562 | 0.82 | TYMS (0.71) | TYMSQTRT1PARP1 | |
| SCHEMBL30249625 | 0.82 | TYMS (0.71) | TYMSQTRT1PARP1 | |
| SCHEMBL7263029 | 0.82 | KDM4E (0.66) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL29535139 | 0.82 | KDM4E (0.66) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL4725175 | 0.79 | TUBB4A (0.55) | TYMSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14239552 | 0.79 | TUBB4A (0.55) | TYMSTUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113880806-B | 2-amino-4-oxo-quinazoline dithiocarbamate derivative, and pharmaceutical composition and application thereof | 深圳大学 | 2022-09-13 | — | — | CN | disclosed |
| US-11219622-B2 | Folate receptor binding conjugates of antifolates | ENDOCYTE, INC. (US) | 2022-01-11 | — | — | US | disclosed |
| CN-113880806-A | 2-amino-4-oxo-quinazoline dithio formate derivative, and pharmaceutical composition and application thereof | 深圳大学 | 2022-01-04 | — | — | CN | disclosed |
| US-20200147072-A1 | Folate Receptor Binding Conjugates of Antifolates | PURDUE RESEARCH FOUNDATION (US) | 2020-05-14 | — | — | US | disclosed |
| US-10363250-B2 | Folate receptor binding conjugates of antifolates | ENDOCYTE, INC. (US) | 2019-07-30 | — | — | US | disclosed |
| US-20170246314-A1 | Folate Receptor Binding Conjugates of Antifolates | PURDUE RESEARCH FOUNDATION (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170246314-A1 | Folate Receptor Binding Conjugates of Antifolates | PURDUE RESEARCH FOUNDATION (US) | 2017-08-31 | — | — | US | disclosed |
| US-9549992-B2 | Folate receptor binding conjugates of antifolates | PURDUE RESEARCH FOUNDATION (US) | 2017-01-24 | — | — | US | disclosed |
| US-9549992-B2 | Folate receptor binding conjugates of antifolates | PURDUE RESEARCH FOUNDATION (US) | 2017-01-24 | — | — | US | disclosed |
| US-20160263237-A1 | Folate Receptor Binding Conjugates of Antifolates | PURDUE RESEARCH FOUNDATION (US) | 2016-09-15 | — | — | US | disclosed |
| US-8546425-B2 | Folate receptor binding conjugates of antifolates | PURDUE RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | disclosed |
| US-8546425-B2 | Folate receptor binding conjugates of antifolates | PURDUE RESEARCH FOUNDATION (US) | 2013-10-01 | — | — | US | disclosed |
| US-20110172254-A1 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES | ENDOCYTE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| US-20110172254-A1 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES | ENDOCYTE, INC. (US) | 2011-07-14 | — | — | US | disclosed |
| WO-2010033733-A1 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES | ENDOCYTE, INC. (US) | 2010-03-25 | — | — | WO | disclosed |
| EP-2139461-A2 | AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER | Recepticon Aps (DK) | 2010-01-06 | — | — | EP | disclosed |
| WO-2008113364-A2 | AMINO DERIVATIVES TO PREVENT NEPHROTOXICITY AND CANCER | RECEPTICON APS (DK) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008109181-A2 | METALLOPROTEASE INHIBITORS CONTAINING A HETEROCYCLIC MOIETY | ALANTOS PHARMACEUTICALS HOLDING, INC. (US) | 2008-09-12 | — | — | WO | disclosed |
| US-20080221095-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221095-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | ALANTOS PHARMACEUTICALS HOLDING, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200147072-A1 | Folate Receptor Binding Conjugates of Antifolates | FOLR1, FOLR2, DHFR | TYMS 29/4885QTRT1 577/4885TUBB4A 1768/4885 |
| US-20160263237-A1 | Folate Receptor Binding Conjugates of Antifolates | FOLR1, FOLR2, DHFR | TYMS 29/4885QTRT1 577/4885TUBB4A 1768/4885 |
| US-11219622-B2 | Folate receptor binding conjugates of antifolates | FOLR1, FOLR2, DHFR | TYMS 29/4885QTRT1 577/4885TUBB4A 1768/4885 |
| US-10363250-B2 | Folate receptor binding conjugates of antifolates | FOLR1, FOLR2, DHFR | TYMS 105/4885QTRT1 636/4885TUBB4A 1474/4885 |
| US-20170246314-A1 | Folate Receptor Binding Conjugates of Antifolates | FOLR1, FOLR2, DHFR | TYMS 105/4885QTRT1 636/4885TUBB4A 1474/4885 |
| US-20080221095-A1 | Metalloprotease inhibitors containing a heterocyclic moiety | MMP13, MMP11, MMP3 | TYMS 2149/4885QTRT1 1129/4885TUBB4A 4427/4885 |
| US-20110172254-A1 | FOLATE RECEPTOR BINDING CONJUGATES OF ANTIFOLATES | FOLR1, FOLR2, DHFR | TYMS 29/4885QTRT1 577/4885TUBB4A 1768/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.