Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 0.50 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.43 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL365228 | 0.90 | HPGD (0.47) | HPGDCNR1TSHRPKMCNR2 | |
| SCHEMBL365334 | 0.87 | L3MBTL1 (0.47) | HPGDCNR1PKMCNR2ALDH1A1 | |
| SCHEMBL367333 | 0.81 | HPGD (0.52) | HPGDCNR1TSHRCNR2GAA | |
| SCHEMBL365667 | 0.81 | EPHX1 (0.56) | TSHRGAASMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL365934 | 0.81 | KDM4E (0.45) | HPGDGAAALDH1A1KDM4EKMT2A | |
| SCHEMBL366810 | 0.79 | PTGS2 (0.45) | TSHRSMN1; SMN2ALDH1A1KDM4EPOLB | |
| SCHEMBL366309 | 0.78 | KDM4E (0.55) | HPGDCNR1CNR2SMN1; SMN2ALDH1A1 | |
| SCHEMBL366875 | 0.77 | EGFR (0.42) | HPGDALDH1A1KDM4ENPC1RAB9A | |
| SCHEMBL365911 | 0.74 | CES1 (0.42) | ALDH1A1KDM4EKMT2A | |
| SCHEMBL366370 | 0.74 | EGFR (0.43) | ALDH1A1KDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | claimed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |
| WO-2012007008-A1 | INHIBITORS OF HDME | EPITHERAPEUTICS APS (DK) | 2012-01-19 | — | — | WO | disclosed |