Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 5/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | MYC | P01106 | 3/20 | 0.42 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | APEX1 | P27695 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4898108 | 0.86 | NOTUM (0.62) | ALDH1A1NOTUMMYCNR4A1 | |
| SCHEMBL480137 | 0.78 | CREBBP (0.58) | ALDH1A1CREBBPMAPTMEN1KMT2A | |
| SCHEMBL11454219 | 0.75 | NOTUM (0.63) | ALDH1A1NOTUMMYCNR4A1MAPT | |
| SCHEMBL11456565 | 0.73 | NOTUM (0.65) | ALDH1A1NOTUMMYCNR4A1MAPT | |
| SCHEMBL11456949 | 0.72 | MEN1 (0.52) | ALDH1A1NOTUMMYCMAPTMEN1 | |
| SCHEMBL3673691 | 0.69 | CREBBP (0.50) | ALDH1A1CREBBPMAPTMEN1KMT2A | |
| SCHEMBL11458707 | 0.69 | ALDH1A1 (0.48) | ALDH1A1NOTUMMAPTKMT2APOLB | |
| SCHEMBL11455602 | 0.68 | NOTUM (0.73) | ALDH1A1NOTUMMAPTMEN1KMT2A | |
| SCHEMBL146048 | 0.67 | KDM4E (0.56) | ALDH1A1NOTUML3MBTL1MAPK1KDM4E | |
| SCHEMBL11457533 | 0.67 | NOTUM (0.69) | ALDH1A1NOTUMMYCNR4A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8383823-B2 | Substituted N-aryl pyridinones | AUSPEX PHARMACEUTICALS (US) | 2013-02-26 | — | — | US | disclosed |
| EP-2170828-B1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | AUSPEX PHARMACEUTICALS INC (US) | 2012-11-21 | — | — | EP | disclosed |
| EP-2170828-A1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | Auspex Pharmaceuticals, Inc. (US) | 2010-04-07 | — | — | EP | disclosed |
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | AUSPEX PHARMACEUTICALS, INC. (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008157786-A1 | SUBSTITUTED N-ARYL PYRIDINONES AS FIBROTIC INHIBITORS | AUSPEX PHARMACEUTICAL, INC. (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080319026-A1 | SUBSTITUTED N-ARYL PYRIDINONES | COL1A1, COL2A1, COLGALT1 | ALDH1A1 293/4885NOTUM 4252/4885CREBBP 1065/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.