SCHEMBL3673942

SCHEMBL3673942

O=C1c2[c]cccc2C(=O)c2[c]cccc21

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDC25B P30305 5/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAOA P21397 5/20 0.39
MAPT P10636 5/20 0.39
KDM4E B2RXH2 4/20 0.39
LMNA P02545 4/20 0.39
CES1 P23141 4/20 0.39
PTPRC P08575 4/20 0.39
BCHE P06276 3/20 0.39
POLB P06746 3/20 0.39
MAPK1 P28482 3/20 0.39
BLM P54132 3/20 0.39
SMN1; SMN2 Q16637 3/20 0.39
APAF1 O14727 2/20 0.39
TDP2 O95551 2/20 0.39
THRB P10828 2/20 0.39
RECQL P46063 2/20 0.39
CES2 O00748 2/20 0.39
PLIN1 O60240 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5506572 0.93 CDC25B (0.55) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL136078 0.93 CDC25B (0.55) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL9366483 0.92 MEN1 (0.46) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL18844 0.88 S100A4 (0.52) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL2077973 0.83 MEN1 (0.55) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL8657198 0.80 S100A4 (0.58) CDC25BMEN1KMT2AMAPTLMNA
SCHEMBL8658476 0.80 ESR2 (0.60) MAOAMAPTPTPRCMAPK1SMN1; SMN2
SCHEMBL21046658 0.80 ALDH1A1 (0.55) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL56824 0.79 CDC25B (0.55) CDC25BMEN1KMT2AMAOAMAPT
SCHEMBL8655894 0.77 EGFR (0.56) MEN1KMT2AMAPTKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0293651-B1 Dicyanovinyl-substituted furan derivatives, process for their preparation, and their use SUEDZUCKER AG (DE) 1994-02-02 EP claimed
US-20100239947-A1 Condensed ring-containing polymer electrolyte and application thereof SUMITOMO CHEMICAL COMPANY, LIMITED 2010-09-23 US disclosed
US-5475076-A Storage under anhydrous conditions; crosslinks in presence of water WACKER-CHEMIE GMBH (DE) 1995-12-12 US disclosed
US-5420222-A Curable organo(poly)siloxane compositions WACKER-CHEMIE GMBH (DE) 1995-05-30 US disclosed
US-5334734-A Vat dyes BASF AKTIENGESELLSCHAFT (DE) 1994-08-02 US disclosed
US-5252757-A Dicyanoazulenyl and dicyanovinyl substituted furan SUDDEUTSCHE ZUCKER-AKTIENGSELLSCHAFT (DE) 1993-10-12 US disclosed
US-5091538-A DICYANOVINYLSUBSTITUTED FURAN DERIVATIVES SUDDEUTSCHE ZUCKER-AKTIENGESELLSCHAFT (DE) 1992-02-25 US disclosed
US-4892899-A Novel compositions based on tetrachloroisoindolinone pigments CIBA-GEIGY CORPORATION (US) 1990-01-09 US disclosed
US-4865650-A FOR COLORING HIGH MOLECULAR WEIGHT COMPONENTS; PAINTS; RHEOLOGY, LUSTER CIBA-GEIGY CORPORATION (US) 1989-09-12 US disclosed
US-4165319-A Isoindoline pigments CIBA-GEIGY CORPORATION (US) 1979-08-21 US disclosed