Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.38 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.33 |
| ▸ | PLA2G5 | P39877 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CTSK | P43235 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692814 | 0.98 | MTNR1A (0.39) | MTNR1AMTNR1BEPHX1TP53HPGD | |
| SCHEMBL27859622 | 0.81 | HRH3 (0.35) | MTNR1AMTNR1BEPHX1TP53HPGD | |
| SCHEMBL28014498 | 0.77 | CYP4F2 (0.42) | TP53ALDH1A1GAA | |
| SCHEMBL10916991 | 0.74 | CYP4F2 (0.44) | TP53ALDH1A1GAA | |
| SCHEMBL5401319 | 0.73 | MGAM (0.44) | ALDH1A1KMT2AGAACA12CA2 | |
| SCHEMBL7976967 | 0.73 | POLB (0.32) | ALDH1A1KMT2A | |
| SCHEMBL28018812 | 0.72 | EPHX1 (0.49) | EPHX1ALDH1A1KMT2AGAACA12 | |
| SCHEMBL11066828 | 0.71 | MGAM (0.46) | ALDH1A1KMT2AGAACA12CA2 | |
| SCHEMBL27456435 | 0.71 | ALDH1A1 (0.38) | TP53HPGDALDH1A1KMT2A | |
| SCHEMBL5233094 | 0.68 | ACHE (0.35) | EPHX1TP53HPGDALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2391611-B1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-04-30 | — | — | EP | disclosed |
| CN-102365273-A | Thiadiazole and oxadiazole derivatives, preparation thereof, and therapeutic use thereof | SANOFI AVENTIS | 2012-02-29 | — | — | CN | disclosed |
| EP-2391611-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2011-12-07 | — | — | EP | disclosed |
| WO-2010086551-A1 | THIADIAZOLE AND OXADIAZOLE DERIVATIVES, PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | SANOFI-AVENTIS (FR) | 2010-08-05 | — | — | WO | disclosed |