Sugi Predict

Sugi Predict / Compounds / SCHEMBL3678596

SCHEMBL3678596

SCHEMBL3678596

COc1ccccc1[Si](C)(C)C

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CA1 P00915 3/20 0.57
▸ CA2 P00918 3/20 0.57
▸ CA7 P43166 2/20 0.57
▸ CA9 Q16790 2/20 0.57
▸ CA12 O43570 1/20 0.57
▸ CA4 P22748 1/20 0.57
▸ CA14 Q9ULX7 1/20 0.57
▸ ALDH1A1 P00352 6/20 0.46
▸ TP53 P04637 2/20 0.46
▸ TDP1 Q9NUW8 2/20 0.46
▸ TSHR P16473 1/20 0.46
▸ ADRA2B P18089 1/20 0.46
▸ PTGS1 P23219 1/20 0.46
▸ MAPK1 P28482 2/20 0.44
▸ HTT P42858 1/20 0.44
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ ENPP2 Q13822 1/20 0.43
▸ NQO2 P16083 3/20 0.42
▸ ORAI1 Q96D31 1/20 0.41
▸ ORAI2 Q96SN7 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2191561 0.85 CA1 (0.57) CA1CA2CA7CA9CA12
SCHEMBL19181561 0.82 CA1 (0.60) CA1CA2CA7CA9CA12
SCHEMBL10998389 0.82 CA1 (0.39) CA1CA2CA7CA9CA12
SCHEMBL31590642 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL16167037 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL5090372 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL3157656 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL27707263 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL2293353 0.81 CA1 (0.52) CA1CA2CA7CA9CA12
SCHEMBL9306231 0.80 CA1 (0.38) CA1CA2CA7CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1671976-B1 Process for the preparation of phosphorus-containing compounds and their intermediates STANFORD RES INST INT (US) 2014-12-03 — — EP disclosed
EP-1785429-B1 PROCESS FOR PRODUCING METALLOCENE COMPOUND SUMITOMO CHEMICAL CO (JP) 2012-10-03 — — EP disclosed
US-7652159-B2 Process for producing metallocene compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-01-26 — — US disclosed
US-20080319213-A1 Process For Producing Metallocene Compound SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2008-12-25 — — US disclosed
EP-1498178-B1 Transition metal complex and process for producing the same SUMITOMO CHEMICAL CO (JP) 2008-06-11 — — EP disclosed
EP-1871776-A2 FUSED THIENO[2,3-B]PYRIDINE AND THIAZOLO[5,4-B]PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY SCHERING CORPORATION (US) 2008-01-02 — — EP disclosed
EP-1785429-A1 PROCESS FOR PRODUCING METALLOCENE COMPOUND Sumitomo Chemical Company, Limited (JP) 2007-05-16 — — EP disclosed
US-20060247320-A1 Compounds for inhibiting KSP kinesin activity SCHERING CORPORATION 2006-11-02 — — US disclosed
WO-2006098961-A2 FUSED THIENO [2, 3-B] PYRIDINE AND THIAZOLO [5, 4-B] PYRIDINE COMPOUNDS FOR INHIBITING KSP KINESIN ACTIVITY SCHERING CORPORATION (US) 2006-09-21 — — WO disclosed
US-7067701-B2 Preparation of phosphorus-containing compounds useful in the preparation of biphosphine ligands SRI INTERNATIONAL (US) 2006-06-27 — — US disclosed
EP-0963990-B1 PROCESS FOR PRODUCING CYCLOPENTADIENYL METAL SALTS AND PROCESS FOR PRODUCING CYCLOPENTADIENE DERIVATIVES BY UTILIZING THE SAME SUMITOMO CHEMICAL CO (JP) 2004-10-06 — — EP disclosed
EP-0842939-B1 OLEFIN POLYMERIZATION CATALYST CONTAINING A TRANSITION METAL COMPLEX AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL CO (JP) 2004-10-06 — — EP disclosed
US-20040147785-A1 Preparation of phosphorus-containing compounds useful in the preparation of biphosphine ligands VAN GINKEL ROELOF (NL) 2004-07-29 — — US disclosed
US-6720442-B2 REACTION LITHIUM PHOSPHINE COMPOUND WITH DIHALPHOSPHINE COMPOUND SRI INTERNATIONAL 2004-04-13 — — US disclosed
US-20030109754-A1 Preparation of phosphorus-containing compounds useful in the preparation of biphosphine ligands VAN GINKEL ROELOF (NL) 2003-06-12 — — US disclosed
US-6548708-B1 Reacting phosphineamine, oxyphosphine or thiophosphine with organic halide; forming polymerization catalyst complexes to make carbon monoxide-A-olefin copolymers SRI INTERNATIONAL 2003-04-15 — — US disclosed
US-6329478-B1 SOLUBILITY IN SATURATED HYDROCARBON SOLVENTS SUMITMO CHEMICAL COMPANY, LIMITED 2001-12-11 — — US disclosed
US-6197990-B1 REACTING CYCLOPENTADIENE AND METAL HYDRIDE IN PRESENCE OF AMINE COMPOUND SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2001-03-06 — — US disclosed
EP-0963990-A1 PROCESS FOR PRODUCING CYCLOPENTADIENYL METAL SALTS AND PROCESS FOR PRODUCING CYCLOPENTADIENE DERIVATIVES BY UTILIZING THE SAME SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-12-15 — — EP disclosed
EP-0842939-A1 TRANSITION METAL COMPLEX, PROCESS FOR THE PREPARATION THEREOF, POLYMERIZATION CATALYST FOR OLEFINS CONTAINING THE COMPLEX, AND PROCESS FOR PRODUCING OLEFIN POLYMERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-05-20 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080319213-A1 Process For Producing Metallocene Compound H1-10, CNOT9, H1-4 CA1 759/4885CA2 2089/4885CA7 2083/4885
US-20060247320-A1 Compounds for inhibiting KSP kinesin activity KIFC1, KIF5B, KIF2C CA1 4410/4885CA2 4033/4885CA7 3841/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.