Water

Water

SCHEMBL3680487

C[N+](C)(C#N)CC(O)CC(=O)[O-].O

nearest known ligand 0.64

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 known ✓ O00255 3/20 0.37
HRH1 known ✓ P35367 1/20 0.37
SLC22A16 Q86VW1 1/20 0.64
CPT2 P23786 2/20 0.41
CPT1A P50416 2/20 0.41
CRAT P43155 1/20 0.41
MAPT P10636 2/20 0.39
KMT2A Q03164 3/20 0.37
CYP1A2 P05177 1/20 0.37
CA4 P22748 2/20 0.35
CA2 P00918 1/20 0.35
CYP2C19 P33261 2/20 0.35
RECQL P46063 1/20 0.35
BBOX1 O75936 1/20 0.31
TP53 P04637 2/20 0.30
CYP2D6 P10635 2/20 0.30
TSHR P16473 2/20 0.30
SLC25A20 O43772 2/20 0.30
CPT1B Q92523 1/20 0.30
KDM4E B2RXH2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3668709 1.00 SLC22A16 (0.64) SLC22A16CPT2CPT1ACRATMAPT
Hydrochloric Acid SCHEMBL3675692 0.98 SLC22A16 (0.62) SLC22A16CPT2CPT1ACRATMAPT
Sulfuric Acid SCHEMBL3672616 0.93 SLC22A16 (0.56) SLC22A16CPT2CPT1ACRATMAPT
Carnitine SCHEMBL27673497 0.84 SLC22A16 (0.83) SLC22A16CPT2CPT1ACRATMAPT
Levocarnitine SCHEMBL23249739 0.81 SLC22A16 (0.95) SLC22A16CPT2CPT1ACRATMAPT
Carnitine SCHEMBL19584826 0.81 SLC22A16 (0.95) SLC22A16CPT2CPT1ACRATMAPT
Carnitine SCHEMBL31299810 0.81 SLC22A16 (0.77) SLC22A16CPT2CPT1ACRATMAPT
SCHEMBL3668668 0.79 SLC22A16 (0.42) SLC22A16CPT2CPT1ACRATMEN1
SCHEMBL6664365 0.79 SLC22A16 (0.42) SLC22A16CPT2CPT1ACRATMEN1
SCHEMBL3669963 0.79 SLC22A16 (0.42) SLC22A16CPT2CPT1ACRATMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7714166-B2 Process for producing carnitinamide MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2010-05-11 US disclosed
US-7714166-B2 Process for producing carnitinamide MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2010-05-11 US disclosed
US-20090143616-A1 Process for Producing Carnitinamide MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2009-06-04 US disclosed
US-20090143616-A1 Process for Producing Carnitinamide MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2009-06-04 US disclosed
EP-1930314-A1 PROCESS FOR PRODUCING CARNITINAMIDE MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2008-06-11 EP disclosed
EP-1930314-A1 PROCESS FOR PRODUCING CARNITINAMIDE MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) 2008-06-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090143616-A1 Process for Producing Carnitinamide CRAT, NISCH, NAAA MEN1 343/4885HRH1 1448/4885SLC22A16 904/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.