Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.47 |
| ▸ | CES1 | P23141 | 1/20 | 0.47 |
| ▸ | DAO | P14920 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13857524 | 0.91 | CES2 (0.39) | CES2CES1DAOHPGDPOLB | |
| SCHEMBL3685299 | 0.83 | MGLL (0.34) | HPGDPOLBNPC1RAB9AKMT2A | |
| SCHEMBL3685296 | 0.77 | ALDH1A1 (0.52) | HPGDPOLBNPC1RAB9AKMT2A | |
| SCHEMBL13857516 | 0.76 | ALDH1A1 (0.51) | HPGDPOLBNPC1RAB9AKMT2A | |
| SCHEMBL13857523 | 0.76 | ALDH1A1 (0.51) | HPGDPOLBNPC1RAB9AKMT2A | |
| SCHEMBL10456409 | 0.75 | NPC1 (0.46) | CES2CES1DAOHPGDPOLB | |
| SCHEMBL13857528 | 0.73 | PKM (0.42) | NPC1RAB9AALDH1A1GAAMAPT | |
| SCHEMBL7651777 | 0.73 | CES2 (0.64) | CES2CES1DAOHPGDPOLB | |
| SCHEMBL22046612 | 0.72 | CA12 (0.35) | HPGDPOLBNPC1RAB9AHTT | |
| SCHEMBL3685351 | 0.72 | MGLL (0.36) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8410150-B2 | Inhibitors of carnitine palmitoyltransferase and treating cancer | UNIVERSITY HEALTH NETWORK (CA) | 2013-04-02 | — | — | US | disclosed |
| US-20100105900-A1 | INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER | UNIVERSITY HEALTH NETWORK | 2010-04-29 | — | — | US | disclosed |
| US-20090137789-A1 | Oligonucleotide Probes | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2009-05-28 | — | — | US | disclosed |
| US-20090137789-A1 | Oligonucleotide Probes | CONSIGLIO NAZIONALE DELLE RICERCHE (IT) | 2009-05-28 | — | — | US | disclosed |
| WO-2008109991-A1 | INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER | UNIVERSITY HEALTH NETWORK (CA) | 2008-09-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105900-A1 | INHIBITORS OF CARNITINE PALMITOYLTRANSFERASE AND TREATING CANCER | CPT1A, CPT1B, CPT2 | CES2 240/4885CES1 69/4885DAO 2881/4885 |
| US-20090137789-A1 | Oligonucleotide Probes | NCL, RNGTT, NSUN3 | CES2 3552/4885CES1 3792/4885DAO 1757/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.