Fluoromisonidazole

Fluoromisonidazole

SCHEMBL368122

O=[N+]([O-])c1nccn1CC(O)CF

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.67
LMNA P02545 1/20 0.47
THRB P10828 1/20 0.47
CYP2C19 P33261 1/20 0.47
CA12 O43570 5/20 0.45
CA1 P00915 5/20 0.45
CA2 P00918 5/20 0.45
CA9 Q16790 5/20 0.45
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
OPRK1 P41145 1/20 0.43
TYMP P19971 3/20 0.43
ALDH1A1 P00352 1/20 0.35
MAPT P10636 1/20 0.35
AGER Q15109 1/20 0.35
NOS1 P29475 1/20 0.35
CHRM1 P11229 1/20 0.33
MEN1 O00255 1/20 0.33
HPGD P15428 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
[18F]Fluoromisonidazole SCHEMBL17022268 1.00 KMT2A (0.67) KMT2ALMNATHRBCYP2C19CA12
[18F]Fluoromisonidazole SCHEMBL13020421 1.00 KMT2A (0.67) KMT2ALMNATHRBCYP2C19CA12
[18F]Fluoromisonidazole SCHEMBL18401354 1.00 KMT2A (0.67) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL12396375 0.91 KMT2A (0.78) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL368113 0.88 KMT2A (0.59) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL16367339 0.88 KMT2A (0.59) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL2358150 0.88 KMT2A (0.71) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL16473558 0.86 KMT2A (0.68) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL15899144 0.85 KMT2A (0.56) KMT2ALMNATHRBCYP2C19CA12
SCHEMBL8897223 0.85 KMT2A (0.67) KMT2ALMNATHRBCYP2C19CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 161 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12583881-B2 Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series OUT AND OUT CHEMISTRY S.P.R.L. (BE) 2026-03-24 US claimed
CN-120081908-A Multifunctional probe based on protein dynamic combination and preparation and application thereof 莎穆(上海)生物科技有限公司 2025-06-03 CN claimed
US-20240350683-A1 PREPARATION OF A PH-ADJUSTED ASCORBIC ACID SOLUTION GE HEALTHCARE LIMITED (GB) 2024-10-24 US claimed
US-20240059724-A1 DEVICE AND CASSETTE FOR PERFORMING A PLURALITY OF SYNTHESIS PROCESSES OF PREPARING A RADIOPHARMACEUTICAL IN SERIES OUT AND OUT CHEMISTRY S.P.R.L. (BE) 2024-02-22 US claimed
CN-117500773-A Method for preparing [18F ] radiolabelled compounds with low water content during the labelling step 通用电气健康护理有限公司 2024-02-02 CN claimed
CN-117500525-A preparation of pH-adjusted ascorbic acid solutions 通用电气健康护理有限公司 2024-02-02 CN claimed
WO-2024006901-A1 USES OF BIPOLAR TRANS CAROTENOIDS IN THE TREATMENT OF CANCER DIFFUSION PHARMACEUTICALS LLC (US) 2024-01-04 WO claimed
CN-117222890-A Analytical HPLC 通用电气健康护理有限公司 2023-12-12 CN claimed
CN-109154671-B Radioactivity detection 赫尔大学 2022-10-04 CN claimed
US-20260144846-A1 Modulation Of Tumor Immunity By Protein-Mediated O2 Delivery OMNIOX, INC. (US) 2026-05-28 US disclosed
US-20260137789-A1 BRUSH PRODRUGS AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2026-05-21 US disclosed
WO-2026090353-A1 METHODS AND RELATED ASPECTS FOR IDENTIFYING TUMOR SUBTYPES THE JOHNS HOPKINS UNIVERSITY (US) 2026-04-30 WO disclosed
EP-3458037-B1 FLUOROCHEMICAL TARGETED THERAPIES MTM RES LLC (US) 2026-04-29 EP disclosed
US-12583881-B2 Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series OUT AND OUT CHEMISTRY S.P.R.L. (BE) 2026-03-24 US disclosed
US-20130295011-A1 BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO VICTORIA LINK LIMITED (NZ) 2013-11-07 US disclosed
EP-2593796-A2 BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO Auckland Uniservices Limited (NZ) 2013-05-22 EP disclosed
US-20120219500-A1 DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES FUJIFILM RI PHARMA CO., LTD. (JP) 2012-08-30 US disclosed
US-20120219500-A1 DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES FUJIFILM RI PHARMA CO., LTD. (JP) 2012-08-30 US disclosed
WO-2012008860-A2 BACTERIAL NITROREDUCTASE ENZYMES AND METHODS RELATING THERETO AUCKLAND UNISERVICES LIMITED (NZ) 2012-01-19 WO disclosed
WO-2011151320-A1 NITROIMIDAZOLE DERIVATIVES GE HEALTHCARE LIMITED (GB) 2011-12-08 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260137789-A1 BRUSH PRODRUGS AND USES THEREOF ABCB11, SLC10A2, CES2 KMT2A 1548/4885LMNA 796/4885THRB 650/4885
US-20240350683-A1 PREPARATION OF A PH-ADJUSTED ASCORBIC ACID SOLUTION PROC, CYP27B1, TTPA KMT2A 2797/4885LMNA 2353/4885THRB 4098/4885
US-20260144846-A1 Modulation Of Tumor Immunity By Protein-Mediated O2 Delivery CD4, HIF1A, HIF1AN KMT2A 2204/4885LMNA 1983/4885THRB 908/4885
US-20120219500-A1 DIAGNOSTIC AGENT FOR INFECTIOUS DISEASES NISCH, CNDP2, MYADM KMT2A 4229/4885LMNA 3487/4885THRB 3937/4885
US-12583881-B2 Device and cassette for performing a plurality of synthesis processes of preparing a radiopharmaceutical in series TMEM14C, FLT1, SLC6A12 KMT2A 3017/4885LMNA 2083/4885THRB 588/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.