Water

Water

SCHEMBL3683454

C[N+]1(Cc2ccccc2)CCCC1.[OH-]

nearest known ligand 0.58

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.58
CHRNB2 P17787 1/20 0.56
CHRNA4 P43681 1/20 0.56
APOBEC3A P31941 2/20 0.44
APOBEC3G Q9HC16 2/20 0.44
PABPC1 P11940 1/20 0.44
EIF4H Q15056 1/20 0.44
KDM4E B2RXH2 1/20 0.43
CTDSP1 Q9GZU7 1/20 0.43
ALDH1A1 P00352 2/20 0.42
HPGD P15428 1/20 0.42
KMT2A Q03164 1/20 0.42
MAPT P10636 1/20 0.42
CHRM3 P20309 2/20 0.41
CYP2D6 P10635 1/20 0.41
CHRM2 P08172 1/20 0.40
CHRM4 P08173 1/20 0.40
CHRM5 P08912 1/20 0.40
CHRM1 P11229 1/20 0.40
HIF1A Q16665 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL723735 0.98 CHRNB2 (0.59) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Water SCHEMBL8939227 0.98 CHRNB2 (0.59) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
SCHEMBL3681307 0.98 CHRNA7 (0.60) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Water SCHEMBL8939226 0.96 CHRNB2 (0.58) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
SCHEMBL10256901 0.96 CHRNB2 (0.61) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Hydrochloric Acid SCHEMBL2458828 0.96 CHRNA7 (0.58) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Iodide SCHEMBL3691022 0.96 CHRNA7 (0.63) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
SCHEMBL724930 0.96 CHRNB2 (0.61) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Bromide SCHEMBL2450495 0.94 CHRNB2 (0.59) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G
Hydrochloric Acid SCHEMBL723900 0.94 CHRNB2 (0.59) CHRNA7CHRNB2CHRNA4APOBEC3AAPOBEC3G

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100168490-A1 METHOD FOR PREPARATION OF AN ALUMINOSILICATE WITH FERRIERITE STRUCTURE FROM GELS CONTAINING TETRAMETHYLAMMONIUM AND BENZYLMETHYLPYRROLIDINE, AND USES THEREOF CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) 2010-07-01 US claimed
US-20100168490-A1 METHOD FOR PREPARATION OF AN ALUMINOSILICATE WITH FERRIERITE STRUCTURE FROM GELS CONTAINING TETRAMETHYLAMMONIUM AND BENZYLMETHYLPYRROLIDINE, AND USES THEREOF CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) 2010-07-01 US disclosed
EP-2133309-A1 METHOD FOR PREPARATION OF AN ALUMINOSILICATE WITH FERRIERITE STRUCTURE FROM GELS CONTAINING TETRAMETHYL AMMONIUM AND BENZYLMETHYLPYRROLIDINE, AND USES THEREOF Consejo Superior De Investigaciones Científicas (ES) 2009-12-16 EP disclosed